ABT-888
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- Product name: ABT-888
- CAS: 912445-05-7
- MF: C13H16N4O
- MW: 244.296
- EINECS:1592732-453-0
- MDL Number:MFCD12407402
- Synonyms:ABT-888;2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide,dihydrochloridesalt;2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride;Veliparib dihydrochloride;ABT-888(Veliparib dihydrochloride);ABT-888 dihydrochloride;ABT888 HCl;Veliparib hydrochloride
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Properties
Melting point :>173°C (dec.)
storage temp. :Refrigerator
solubility :Methanol (Slightly, Heated), THF (Slightly, Heated)
form :Colorless to white crystalline solid.
color :Off-White to Dark Yellow
storage temp. :Refrigerator
solubility :Methanol (Slightly, Heated), THF (Slightly, Heated)
form :Colorless to white crystalline solid.
color :Off-White to Dark Yellow
Safety Information
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Description
Poly(ADP-ribose) polymerases (PARPs) have diverse roles in cellular processes, including DNA repair and apoptosis. ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively). It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation. ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively). It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation. ABT-888 also acts synergistically with chemotherapies to increase the lethal effects of radiation in cancer cells.More related product prices
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