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4-AMINO-1,8-NAPHTHALIMIDE

4-AMINO-1,8-NAPHTHALIMIDE Structure
  • ₹9180 - ₹27521
  • Product name: 4-AMINO-1,8-NAPHTHALIMIDE
  • CAS: 1742-95-6
  • MF: C12H8N2O2
  • MW: 212.2
  • EINECS:217-110-1
  • MDL Number:MFCD00006921
  • Synonyms:4-Amino-1,8-naphthalenedicarbimide;4-Amino-1,8-naphthalenedicarboximide;4-Aminonaphthalene-1,8-dicarbimide;6-Amino-2,3-dihydro-1H-benzo[de]isoquinoline-1,3-dione;6-Amino-2H-benzo[de]isoquinoline-1,3-dione;4-Amino-1,8-naphthalimide,98%;6-amino-1h-benz(de)isoquinoline-3(2h)-dione ;6-amino-1h-benz[de]isoquinoline-3(2h)-dione
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)
  • ALFA India

Package

  • 20MG
  • 100mg
  • 1g
  • ManufacturerSigma-Aldrich(India)
  • Product numberA0966
  • Product description4-Amino-1,8-naphthalimide
  • Packaging20MG
  • Price₹15458.1
  • Updated2022-06-14
  • Buy
  • ManufacturerALFA India
  • Product numberALF-J64358-03
  • Product description4-Amino-1,8-naphthalimide, 95%
  • Packaging1g
  • Price₹27521
  • Updated2022-05-26
  • Buy
  • ManufacturerALFA India
  • Product numberALF-J64358-MC
  • Product description4-Amino-1,8-naphthalimide, 95%
  • Packaging100mg
  • Price₹9180
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) A0966 4-Amino-1,8-naphthalimide 20MG ₹15458.1 2022-06-14 Buy
ALFA India ALF-J64358-03 4-Amino-1,8-naphthalimide, 95% 1g ₹27521 2022-05-26 Buy
ALFA India ALF-J64358-MC 4-Amino-1,8-naphthalimide, 95% 100mg ₹9180 2022-05-26 Buy

Properties

Melting point :360 °C
Boiling point :352.04°C (rough estimate)
Density :1.105 g/mL at 25 °C(lit.)
vapor pressure :0Pa at 25℃
refractive index :1.6000 (estimate)
storage temp. :-20°C
solubility :Soluble in DMSO
form :Orange solid.
pka :9.53±0.20(Predicted)
color :Yellow to brown
Water Solubility :354mg/L at 25℃
LogP :1.08
CAS DataBase Reference :1742-95-6
EPA Substance Registry System :1H-Benz[de]isoquinoline-1,3(2H)-dione, 6-amino- (1742-95-6)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM). It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation. 4-ANI is used to study the role of PARP activity in various cell systems.

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1,8-Naphthalimide 4-Amino-1,8-naphthalic anhydride

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