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4-AMINO-1,8-NAPHTHALIMIDE

4-AMINO-1,8-NAPHTHALIMIDE Structure
CAS No.
1742-95-6
Chemical Name:
4-AMINO-1,8-NAPHTHALIMIDE
Synonyms
dfp1;4-ANI;TIMTEC-BB SBB003425;4-aminonaphthalimide;4-amino-naphthalimid;4-AMINO-1,8-NAPHTHALIMIDE;4-Amino-1,8-naphthalimide,98%;4-AMINO-1,8-NAPHTHALIMIDE 98%;4-amino-1-hydroxy-7H-purin-6-ol;4-Amino-1,8-naphthalenedicarbimide
CBNumber:
CB0774002
Molecular Formula:
C12H8N2O2
Molecular Weight:
212.2
MOL File:
1742-95-6.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:54:58
Request For Quotation

4-AMINO-1,8-NAPHTHALIMIDE Properties

Melting point 360 °C
Boiling point 352.04°C (rough estimate)
Density 1.105 g/mL at 25 °C(lit.)
vapor pressure 0Pa at 25℃
refractive index 1.6000 (estimate)
storage temp. -20°C
solubility Soluble in DMSO
form Orange solid.
pka 9.53±0.20(Predicted)
color Yellow to brown
Water Solubility 354mg/L at 25℃
LogP 1.08
CAS DataBase Reference 1742-95-6
EPA Substance Registry System 1H-Benz[de]isoquinoline-1,3(2H)-dione, 6-amino- (1742-95-6)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
RTECS  DE4081000
TSCA  Yes
HS Code  29251995

4-AMINO-1,8-NAPHTHALIMIDE price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) A0966 4-Amino-1,8-naphthalimide 1742-95-6 20MG ₹15458.1 2022-06-14 Buy
ALFA India ALF-J64358-MC 4-Amino-1,8-naphthalimide, 95% 1742-95-6 100mg ₹9180 2022-05-26 Buy
ALFA India ALF-J64358-03 4-Amino-1,8-naphthalimide, 95% 1742-95-6 1g ₹27521 2022-05-26 Buy
Product number Packaging Price Buy
A0966 20MG ₹15458.1 Buy
ALF-J64358-MC 100mg ₹9180 Buy
ALF-J64358-03 1g ₹27521 Buy

4-AMINO-1,8-NAPHTHALIMIDE Chemical Properties,Uses,Production

Description

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM). It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation. 4-ANI is used to study the role of PARP activity in various cell systems.

Chemical Properties

orange amorphous powder

Uses

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM). It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation. 4-ANI is used to study the role of PARP activity in various cell systems.

Enzyme inhibitor

This PARP inhibitor (FW = 212.21 g/mol) is a strong inhibitor of NAD:ADP-ribosyltransferase or poly(ADP-ribose) polymerase (IC50 = 0.18 μM). In addition, 4-Amino-1,8-naphthalimide is a radiation sensitizer at non-toxic and low concentrations.

4-AMINO-1,8-NAPHTHALIMIDE Preparation Products And Raw materials

Raw materials

ACENAPHTHYLENE Sodium dichromate dihydrate Nitric acid Acetic acid Ammonia

Preparation Products

4-AMINO-1,8-NAPHTHALIMIDE Suppliers

Global( 75)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Alfa Aesar 1 800 209 7001 Maharashtra, India 6913 58 Inquiry
Shenzhen Nexconn Pharmatechs Ltd +86-755-89396905 +86-15013857715 China 10311 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49403 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. 571-88938639 +8617705817739 China 52861 58 Inquiry
GIHI CHEMICALS CO.,LIMITED +8618058761490 China 50003 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Alfa Aesar 58
Shenzhen Nexconn Pharmatechs Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
GIHI CHEMICALS CO.,LIMITED 58
LEAPCHEM CO., LTD. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58

4-AMINO-1,8-NAPHTHALIMIDE Spectrum

4-AMINO-1,8-NAPHTHALIMIDE(1742-95-6)MS4-AMINO-1,8-NAPHTHALIMIDE(1742-95-6)1HNMR4-AMINO-1,8-NAPHTHALIMIDE(1742-95-6)IR14-AMINO-1,8-NAPHTHALIMIDE(1742-95-6)Raman

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