4-Hydroxyquinazoline
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- ₹1800 - ₹8264
- Product name: 4-Hydroxyquinazoline
- CAS: 491-36-1
- MF: C8H6N2O
- MW: 146.15
- EINECS:207-735-8
- MDL Number:MFCD00511302
- Synonyms:4(3H)-Quinazolone;4-Quinazolinone;Quinazolone, 4-;quinazolidin-4-one;1H-quinazolin-4-one;TIMTEC-BB SBB005858;AURORA 17795;4-HYDROXYQUINAZOLINE
5 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
- ALFA India
Package
- 5G
- 10g
- 25G
- 50g
- ManufacturerTCI Chemicals (India)
- Product numberH0803
- Product description4-Hydroxyquinazoline
- Packaging5G
- Price₹1800
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberH0803
- Product description4-Hydroxyquinazoline
- Packaging25G
- Price₹4900
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberH57807
- Product description4-Hydroxyquinazoline 98%
- Packaging5G
- Price₹1980.98
- Updated2022-06-14
- Buy
- ManufacturerALFA India
- Product numberALF-A17129-18
- Product description4-Hydroxyquinazoline, 98%
- Packaging50g
- Price₹8264
- Updated2022-05-26
- Buy
- ManufacturerALFA India
- Product numberALF-A17129-09
- Product description4-Hydroxyquinazoline, 98%
- Packaging10g
- Price₹3087
- Updated2022-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | H0803 | 4-Hydroxyquinazoline | 5G | ₹1800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | H0803 | 4-Hydroxyquinazoline | 25G | ₹4900 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | H57807 | 4-Hydroxyquinazoline 98% | 5G | ₹1980.98 | 2022-06-14 | Buy |
| ALFA India | ALF-A17129-18 | 4-Hydroxyquinazoline, 98% | 50g | ₹8264 | 2022-05-26 | Buy |
| ALFA India | ALF-A17129-09 | 4-Hydroxyquinazoline, 98% | 10g | ₹3087 | 2022-05-26 | Buy |
Properties
Melting point :216-219 °C (lit.)
Boiling point :265.75°C (rough estimate)
Density :1.2312 (rough estimate)
vapor pressure :0.015Pa at 20℃
refractive index :1.4900 (estimate)
storage temp. :Sealed in dry,Room Temperature
solubility :Soluble in DMSO (up to 14 mg/ml) or in Water (up to 1 mg/ml).
form :Crystalline Powder
pka :2.69±0.20(Predicted)
color :Off-white to light beige
Water Solubility :Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).
Sensitive :Hygroscopic
BRN :118473
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
InChIKey :QMNUDYFKZYBWQX-UHFFFAOYSA-N
LogP :0.94 at 20℃
CAS DataBase Reference :491-36-1(CAS DataBase Reference)
NIST Chemistry Reference :4(1H)-quinazolinone(491-36-1)
Boiling point :265.75°C (rough estimate)
Density :1.2312 (rough estimate)
vapor pressure :0.015Pa at 20℃
refractive index :1.4900 (estimate)
storage temp. :Sealed in dry,Room Temperature
solubility :Soluble in DMSO (up to 14 mg/ml) or in Water (up to 1 mg/ml).
form :Crystalline Powder
pka :2.69±0.20(Predicted)
color :Off-white to light beige
Water Solubility :Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).
Sensitive :Hygroscopic
BRN :118473
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
InChIKey :QMNUDYFKZYBWQX-UHFFFAOYSA-N
LogP :0.94 at 20℃
CAS DataBase Reference :491-36-1(CAS DataBase Reference)
NIST Chemistry Reference :4(1H)-quinazolinone(491-36-1)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.Related product price
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