ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Quinoline compounds >4-Hydroxyquinazoline
4-Hydroxyquinazoline
- CAS No.
- 491-36-1
- Chemical Name:
- 4-Hydroxyquinazoline
- Synonyms
- QUINAZOLIN-4(3H)-ONE;QUINAZOLINONE;4-Oxoquinazoline;QUINAZOLIN-4-OL;quinazolin-4(1H)-one;QUINAZOLONE;4-HQN;β-Nitropropionic acid;AKOS 219-06;AURORA 17795
- CBNumber:
- CB5182082
- Molecular Formula:
- C8H6N2O
- Molecular Weight:
- 146.15
- MOL File:
- 491-36-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/9 22:15:29
| Melting point | 216-219 °C (lit.) |
|---|---|
| Boiling point | 265.75°C (rough estimate) |
| Density | 1.2312 (rough estimate) |
| vapor pressure | 0.015Pa at 20℃ |
| refractive index | 1.4900 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO (up to 14 mg/ml) or in Water (up to 1 mg/ml). |
| form | Crystalline Powder |
| pka | 2.69±0.20(Predicted) |
| color | Off-white to light beige |
| Water Solubility | Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM). |
| Sensitive | Hygroscopic |
| BRN | 118473 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month. |
| InChIKey | QMNUDYFKZYBWQX-UHFFFAOYSA-N |
| LogP | 0.94 at 20℃ |
| CAS DataBase Reference | 491-36-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 4(1H)-quinazolinone(491-36-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-37/39-36/37/39-22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VA2300000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29335995 | |||||||||
| NFPA 704 |
|
4-Hydroxyquinazoline price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | H57807 | 4-Hydroxyquinazoline 98% | 491-36-1 | 5G | ₹1980.98 | 2022-06-14 | Buy |
| TCI Chemicals (India) | H0803 | 4-Hydroxyquinazoline | 491-36-1 | 5G | ₹1800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | H0803 | 4-Hydroxyquinazoline | 491-36-1 | 25G | ₹4900 | 2022-05-26 | Buy |
| ALFA India | ALF-A17129-18 | 4-Hydroxyquinazoline, 98% | 491-36-1 | 50g | ₹8264 | 2022-05-26 | Buy |
| ALFA India | ALF-A17129-09 | 4-Hydroxyquinazoline, 98% | 491-36-1 | 10g | ₹3087 | 2022-05-26 | Buy |
4-Hydroxyquinazoline Chemical Properties,Uses,Production
Chemical Properties
off-white to light beige crystalline powder
Uses
4-Hydroxyquinazoline shows anti-microbial and anti-carcinogenic activity as seen in studies due to the quinazoline moiety.
Biological Activity
Inhibitor of poly(ADP-ribose) polymerase (PARP) (IC 50 = 9.5 μ M); displays mixed inhibition with respect to NAD + . Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart. Anti-inflammatory in LPS-induced endotoxic mice in vivo ; decreases NF- κ B and AP-1 activation.
4-Hydroxyquinazoline Preparation Products And Raw materials
Global( 358)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| SREE SYNERIC LAB | null | New Delhi, India | 328 | 58 | Inquiry |
| Jyoti Chemical Centre | 09594652522 | Mumbai, India | 215 | 58 | Inquiry |
| Innovative Synthetic Molecules | +91 40-24111684 | Hyderabad, India | 527 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20290 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Supplier | Advantage |
|---|---|
| CHEMSWORTH | 30 |
| A.J Chemicals | 58 |
| Alfa Aesar | 58 |
| SREE SYNERIC LAB | 58 |
| Jyoti Chemical Centre | 58 |
| Innovative Synthetic Molecules | 58 |
| HiMedia Laboratories | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Henan Fengda Chemical Co., Ltd | 58 |
| Capot Chemical Co.,Ltd. | 60 |
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