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1,5-ISOQUINOLINEDIOL

1,5-ISOQUINOLINEDIOL Structure
  • ₹5980 - ₹9490
  • Product name: 1,5-ISOQUINOLINEDIOL
  • CAS: 5154-02-9
  • MF: C9H7NO2
  • MW: 161.16
  • EINECS:637-104-6
  • MDL Number:MFCD00006900
  • Synonyms:1,5-ISOQUINOLINEDIOL;1,5-DIHYDROXYISOQUINOLINE;5-HYDROXYISOCARBOSTYRIL;5-HYDROXY-1(2H)-ISOQUINOLINE;5-HYDROXY-1(2H)-ISOQUINOLINONE;1,5-ISOQUINOLINEDIOL(1,5-DIHYDROXYISOQUI NO-LINE);1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinolinone, DiQ;5-Hydroxyisoquinoline-1(2H)-one
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberI138
  • Product description1,5-Isoquinolinediol ≥98% (HPLC), powder
  • Packaging5MG
  • Price₹5980
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number419800
  • Product descriptionPARP Inhibitor IV, IQD - CAS 1188540 - Calbiochem The PARP Inhibitor IV, IQD, also referenced under CAS 1188540, controls the biological activity of PARP. This small molecule/inhibitor is primarily us
  • Packaging5MG
  • Price₹9490
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) I138 1,5-Isoquinolinediol ≥98% (HPLC), powder 5MG ₹5980 2022-06-14 Buy
Sigma-Aldrich(India) 419800 PARP Inhibitor IV, IQD - CAS 1188540 - Calbiochem The PARP Inhibitor IV, IQD, also referenced under CAS 1188540, controls the biological activity of PARP. This small molecule/inhibitor is primarily us 5MG ₹9490 2022-06-14 Buy

Properties

Melting point :270-275 °C
Boiling point :287.44°C (rough estimate)
Density :1.2480 (rough estimate)
refractive index :1.5050 (estimate)
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :DMSO: >36 mg/mL
form :solid
pka :8.52±0.20(Predicted)
color :off-white
CAS DataBase Reference :5154-02-9(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P233 Keep container tightly closed.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304 IF INHALED:
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P340 Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362 Take off contaminated clothing and wash before reuse.
P403 Store in a well-ventilated place.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50 = 0.39 μM). It has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound can be used with cells in culture and in animals.

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