1,5-ISOQUINOLINEDIOL

CAS No.: 5154-02-9

Chemical Name:: 1,5-ISOQUINOLINEDIOL

Synonyms: DHQ;DIQ;NSC 65585;1,5-ISOQUINOLINEDIOL;isoquinoline-1,5-diol;5-HYDROXYISOCARBOSTYRIL;1,5-Isoquinolinediol,98%;5-Hydroxy-isoquinolinone;1,5-DIHYDROXYISOQUINOLINE;1,5-Isoquinolinediol ,97%

CBNumber:: CB5360303

Molecular Formula:: C9H7NO2

Molecular Weight:: 161.16

MOL File:: 5154-02-9.mol

MSDS File:: SDS

Modify Date:: 2023/6/30 15:45:59

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1,5-ISOQUINOLINEDIOL Properties

Melting point	270-275 °C
Boiling point	287.44°C (rough estimate)
Density	1.2480 (rough estimate)
refractive index	1.5050 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO: >36 mg/mL
form	solid
pka	8.52±0.20(Predicted)
color	off-white
CAS DataBase Reference	5154-02-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39

WGK Germany

HS Code

29337900

NFPA 704

	0
2		0

1,5-ISOQUINOLINEDIOL price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	I138	1,5-Isoquinolinediol ≥98% (HPLC), powder	5154-02-9	5MG	₹5980	2022-06-14	Buy
Sigma-Aldrich(India)	419800	PARP Inhibitor IV, IQD - CAS 1188540 - Calbiochem The PARP Inhibitor IV, IQD, also referenced under CAS 1188540, controls the biological activity of PARP. This small molecule/inhibitor is primarily us	5154-02-9	5MG	₹9490	2022-06-14	Buy

Product number	Packaging	Price	Buy
I138	5MG	₹5980	Buy
419800	5MG	₹9490	Buy

1,5-ISOQUINOLINEDIOL Chemical Properties,Uses,Production

Description

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC₅₀ = 0.39 μM). It has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound can be used with cells in culture and in animals.

Chemical Properties

white to off-white solid

Uses

1,5-Isoquinolinediol can be used as a reagent in the preparation of PARP inhibitor.

Definition

ChEBI: An isoquinolinol that is isoquinoline in which the hydrogens at positions 1 and 5 are replaced by hydroxy groups.

General Description

A potent inhibitor of poly(ADP-ribose) polymerase (PARP; IC₅₀ = 390 nM). Reported to partially block SNAP (CN 487910)- induced cell death in SH-SYSY human neuroblastoma cells.

1,5-ISOQUINOLINEDIOL Preparation Products And Raw materials

Raw materials

Preparation Products

ethyl 2-[(1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]propanoate

1,5-ISOQUINOLINEDIOL Suppliers

Global( 103)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	China	34571	58	Inquiry
WinWin Chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	China	14279	58	Inquiry
Wuhan Fortuna Chemical Co., Ltd	+86-027-59207850	China	5992	58	Inquiry
Henan Alfa Chemical Co., Ltd	+8618339805032	China	13141	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	China	20308	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
Capot Chemical Co.,Ltd.	60
CONIER CHEM AND PHARMA LIMITED	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
WinWin Chemical CO., Limited	58
Wuhan Fortuna Chemical Co., Ltd	58
Henan Alfa Chemical Co., Ltd	58
TargetMol Chemicals Inc.	58
LEAPCHEM CO., LTD.	58
Henan Fengda Chemical Co., Ltd	58

5154-02-9(1,5-ISOQUINOLINEDIOL)Related Search:

1,5-ISOQUINOLINEDIOL 7-isoquinolinediol,1-((3,4-dihydroxyphenyl)methyl)-1,2,3,4-tetrahydro-h 1,2,3,4-TETRAHYDRO-1-METHYL-6,7-ISOQUINOLINEDIOL HYDROBROMIDE,1,2,3,4-Tetrahydro-1-methyl-6,7-Isoquinolinediol 1-[(3,4-Dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-2-methyl-6,7-isoquinolinediol 5-Hydroxyisoquinoline

Isoquinoline Isocarbostyril 1,2,3,4-TETRAHYDRO-6,7-ISOQUINOLINEDIOL HYDROBROMIDE,1,2,3,4-TETRAHYDRO-6,7-ISOQUINOLINEDIOL HYDROBROMIDE 98% 1-(3,4-Dihydroxybenzyl)-6,7-isoquinolinediol Tretoquinol

(S)-1,2,3,4-tetrahydro-6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride 5-METHOXY-2H-ISOQUINOLIN-1-ONE 6,7-Isoquinolinediol, 1-propyl- (9CI) d-1-(3,4,5-Trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline 6,7-Isoquinolinediol, 1-(1-methylethyl)- (9CI)

6,7-Isoquinolinediol, 1-[(1S)-1,2-dihydroxyethyl]-1,2,3,4-tetrahydro- (9CI) 3,4-Dihydro-6,7-isoquinolinediol. Tretoquinol hydrochloride

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1,5-ISOQUINOLINEDIOL 1,5-DIHYDROXYISOQUINOLINE 5-HYDROXYISOCARBOSTYRIL 5-HYDROXY-1(2H)-ISOQUINOLINE 5-HYDROXY-1(2H)-ISOQUINOLINONE 1,5-ISOQUINOLINEDIOL(1,5-DIHYDROXYISOQUI NO-LINE) 1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinolinone, DiQ 5-Hydroxyisoquinoline-1(2H)-one DHQ 1,5-Isoquinolinediol,98% 1,5-dihydroxy-1(2H)-isoquinoline 1,5-Isoquinolinediol ,97% isoquinoline-1,5-diol 5-hydroxyisoquinolin-1(2H)-one 5-Hydroxy-isoquinolinone NSC 65585 DIQ 1(2H)-Isoquinolinone, 5-hydroxy- 5-hydroxy-1,2-dihydroisoquinolin-1-one Isoquinolinediol, 1,5- - NSC 65585 PARP,diabetic,1188540,oxidative,retinopathy,1,5 Isoquinolinediol,stress,inhibit,NADPH,1,5-Isoquinolinediol,Inhibitor,1,5Isoquinolinediol,oxidase,poly ADP ribose polymerase 5154-02-9 PARP Regulators PARP BioChemical Apoptosis and Cell Cycle Cell Signaling and Neuroscience Cell Biology Aromatics Inhibitors