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ERK Inhibitor

ERK Inhibitor Structure
  • ₹0
  • Product name: ERK Inhibitor
  • CAS: 1049738-54-6
  • MF: C14H17ClN2O3S
  • MW: 328.81
  • EINECS:
  • MDL Number:MFCD09038681
  • Synonyms:(5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride;ERK Inhibitor - CAS 1049738-54-6 - Calbiochem;3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride;ERK-IN-4
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

storage temp. :+2C to +8C
solubility :DMSO: 2 mg/ml
form :Light yellow solid
color :Off-white to yellow

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 μM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2. Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC50 = 15-20 μM), A549 lung carcinoma cells (IC50 = 25 μM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells.

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Suppliers and manufacturers

Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
Wuhan Topule Biopharmaceutical Co., Ltd
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
Aladdin Scientific Shanghai Zhiyun Biotechnology Co., Ltd Shanghai Aladdin Biochemical Technology Co.,Ltd. Olix (Shanghai) Pharmaceutical Technology Co., Ltd TargetMol Chemicals Inc. Wuhan Topule Wuhan Augda Biotechnology Co., Ltd