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ERK Inhibitor

ERK Inhibitor Structure
CAS No.
1049738-54-6
Chemical Name:
ERK Inhibitor
Synonyms
ERK-IN-4;ERK Inhibitor - CAS 1049738-54-6 - Calbiochem;3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride;(5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride
CBNumber:
CB13136749
Molecular Formula:
C14H17ClN2O3S
Molecular Weight:
328.81
MOL File:
1049738-54-6.mol
Modify Date:
2024/7/2 8:55:00
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ERK Inhibitor Properties

storage temp. +2C to +8C
solubility DMSO: 2 mg/ml
form Light yellow solid
color Off-white to yellow

ERK Inhibitor Chemical Properties,Uses,Production

Description

ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 μM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2. Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC50 = 15-20 μM), A549 lung carcinoma cells (IC50 = 25 μM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells.

General Description

A cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC50 ≤ 25 μM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a KD of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.

Biochem/physiol Actions

Primary TargetERK

ERK Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

ERK Inhibitor Suppliers

Global( 26)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd +8618829768577 China 1250 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd +86-19164747840 +86-13119157289 China 2969 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Shanghai Zhiyun Biotechnology Co., Ltd 13119135307 China 2694 58 Inquiry
Shanghai Aladdin Biochemical Technology Co.,Ltd. +86-18521732826 China 48467 58 Inquiry
Olix (Shanghai) Pharmaceutical Technology Co., Ltd 17316404525 China 9626 58 Inquiry
Wuhan Augda Biotechnology Co., Ltd 15071299552 China 6637 58 Inquiry
TargetMol Chemicals Inc. 15002134094 China 28118 58 Inquiry
Wuhan Topule +86-02787215551 +86-19945035818 China 8234 58 Inquiry
Supplier Advantage
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 58
Aladdin Scientific 58
Shanghai Zhiyun Biotechnology Co., Ltd 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 58
Olix (Shanghai) Pharmaceutical Technology Co., Ltd 58
Wuhan Augda Biotechnology Co., Ltd 58
TargetMol Chemicals Inc. 58
Wuhan Topule 58

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(5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride ERK Inhibitor - CAS 1049738-54-6 - Calbiochem 3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride ERK-IN-4 1049738-54-6