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ERK Inhibitor

ERK Inhibitor Structure
CAS No.
1049738-54-6
Chemical Name:
ERK Inhibitor
Synonyms
ERK-IN-4;ERK Inhibitor - CAS 1049738-54-6 - Calbiochem;3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride;(5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride
CBNumber:
CB13136749
Molecular Formula:
C14H17ClN2O3S
Molecular Weight:
328.82
MOL File:
1049738-54-6.mol
MSDS File:
SDS
Modify Date:
2026/7/27 17:00:41
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ERK Inhibitor Properties

storage temp. +2C to +8C
solubility DMSO: 2 mg/ml
form Light yellow solid
color Off-white to yellow
InChIKey PQVLWVGMXJPJLG-UHFFFAOYSA-N
SMILES S1C(=O)N(C(=O)C1=Cc2ccc(cc2)OCC)CCN.Cl

SAFETY

Risk and Safety Statements

WGK Germany  WGK 1
Storage Class 11 - Combustible Solids

ERK Inhibitor price

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ERK Inhibitor Chemical Properties,Uses,Production

Description

ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 μM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2. Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC50 = 15-20 μM), A549 lung carcinoma cells (IC50 = 25 μM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells.

General Description

A cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC50 ≤ 25 μM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a KD of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.

Biochem/physiol Actions

Primary TargetERK

ERK Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

ERK Inhibitor Suppliers

Global( 39)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 United States 32431 58 Inquiry
BOC Sciences 16314854226; +8616314854226 United States 19852 58 Inquiry
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd +86-19891622721 China 1243 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +86-18327326525 China 8433 58 Inquiry
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd +86-13119157289 China 3390 58 Inquiry
Aladdin Scientific United States 54732 58 Inquiry
DAYANG CHEM (HANGZHOU) CO.,LTD +86-88938639 +86-17705817739 China 53586 58 Inquiry
ComMedX (Computational Medicine Beijing Co., Ltd.) +86-18519000250 +86-18519000250 China 258 58 Inquiry
commedx 1851900025 China 422 58 Inquiry
Shanghai Amole Biotechnology Co., Ltd. 13370042665 18916960931 China 17234 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
BOC Sciences 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 58
Aladdin Scientific 58
DAYANG CHEM (HANGZHOU) CO.,LTD 58
ComMedX (Computational Medicine Beijing Co., Ltd.) 58
commedx 58
Shanghai Amole Biotechnology Co., Ltd. 58

ERK Inhibitor Spectrum

ERK Inhibitor(1049738-54-6)1HNMR

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(5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride ERK Inhibitor - CAS 1049738-54-6 - Calbiochem 3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride ERK-IN-4 1049738-54-6