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ERK Inhibitor

ERK Inhibitor Structure
CAS No.
1049738-54-6
Chemical Name:
ERK Inhibitor
Synonyms
ERK-IN-4;ERK Inhibitor - CAS 1049738-54-6 - Calbiochem;3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride;(5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride
CBNumber:
CB13136749
Molecular Formula:
C14H17ClN2O3S
Molecular Weight:
328.81
MOL File:
1049738-54-6.mol
Modify Date:
2025/4/18 9:51:39
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ERK Inhibitor Properties

storage temp. +2C to +8C
solubility DMSO: 2 mg/ml
form Light yellow solid
color Off-white to yellow

ERK Inhibitor Chemical Properties,Uses,Production

Description

ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 μM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2. Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC50 = 15-20 μM), A549 lung carcinoma cells (IC50 = 25 μM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells.

General Description

A cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC50 ≤ 25 μM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a KD of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.

Biochem/physiol Actions

Primary TargetERK

ERK Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

ERK Inhibitor Suppliers

Global( 37)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +17819995354 United States 32294 58 Inquiry
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd +8618829768577 China 1249 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8467 58 Inquiry
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd +8618791163155 China 3478 58 Inquiry
Aladdin Scientific United States 57505 58 Inquiry
DAYANG CHEM (HANGZHOU) CO.,LTD +86-88938639 +86-17705817739 China 53900 58 Inquiry
Merck Millipore 1-400-889-1988 400-889-1988 China 6839 58 Inquiry
Cayman Chemical Company 800-364-9897 China 6838 58 Inquiry
Santa Cruz Biotechnology Inc 021-60936350 China 6594 58 Inquiry
commedx 010-46598925 18519000250 China 340 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 58
Aladdin Scientific 58
DAYANG CHEM (HANGZHOU) CO.,LTD 58
Merck Millipore 58
Cayman Chemical Company 58
Santa Cruz Biotechnology Inc 58
commedx 58

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(5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride ERK Inhibitor - CAS 1049738-54-6 - Calbiochem 3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride ERK-IN-4 1049738-54-6