NSC 23766 TETRAHYDROCHLORIDE
- CAS No.
- 733767-34-5
- Chemical Name:
- NSC 23766 TETRAHYDROCHLORIDE
- Synonyms
- CS-594;CS-1187;NSC 23766;NPEC-caged-(1S;NSC23766;NSC 23766;NSC-23766 free base;NSC 23766 TETRAHYDROCHLORIDE;N6-(2-(5-(Diethylamino)pentan-2-ylamino)-6-methylpyrimidin-4-yl)-2-methylquinoline-4,6-diamine;4,6-Quinolinediamine, N6-[2-[[4-(diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-;N6-[2-(4-Diethylamino-1-methylbutylamino)-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine tetrahydrochloride
- CBNumber:
- CB6504010
- Molecular Formula:
- C24H35N7
- Molecular Weight:
- 421.58
- MOL File:
- 733767-34-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/4 17:34:41
| storage temp. | Desiccate at RT |
|---|---|
| solubility | Soluble in DMSO (50 mg/ml); Water (50 mg/ml) |
| form | White powder solid. |
| color | White |
| Water Solubility | Soluble in water. |
| Sensitive | Light Sensitive & Hygroscopic |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
NSC 23766 TETRAHYDROCHLORIDE Chemical Properties,Uses,Production
Uses
The compound blocks activation by the guanine nucleotide exchange factors Trio and Tiam1, but does not affect interactions with RhoA or Cdc42. NSC23766 blocks ADP-mediated platelet aggregation. Inhibition of Rac1 by NSC23766 restores sensitivity to trastuzumab by restoring down-regulation of ErbB2. Membrane type 1-matrix metalloproteinases (MT-1MMP) expression in CB CD34+ cells has been reported to decrease in the presence of NSC 23766. Silveta compress investigations indicate that NSC 23766 depolarizes endomembrane cycling, altered polar adhesive secretion, and tip growth.
Biological Activity
Selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC 50 ~ 50 μ M) without affecting Cdc42 or RhoA activation. Inhibits Rac1-mediated cell functions and reported to reverse tumor cell phenotyes in prostate cancer cells.
NSC 23766 TETRAHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
NSC 23766 TETRAHYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | China | 9991 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| Beijing Anbiqi Biotechnology Co., Ltd. | 15811277462 | CHINA | 2529 | 58 | Inquiry |
| Shanghai Shanran Biotechnology Co., Ltd. | 15900853496 | CHINA | 1563 | 58 | Inquiry |
| Wuhan Boot Biotechnology Co., Ltd. | 027-87663101 15827569716 | CHINA | 6829 | 58 | Inquiry |
| Shanghai Han-Xiang Chemical Co., Ltd. | +86 (21) 5027-2946, +86 13818785766 | China | 1039 | 50 | Inquiry |
| Shanghai Yuda Industrial Co., Ltd. | 021-64133189 13788995069 | CHINA | 6107 | 58 | Inquiry |
| Shanghai Chaoyan Biotechnology Co., Ltd. | 021-50840550 | CHINA | 6217 | 58 | Inquiry |