KENPAULLONE
- CAS No.
- 142273-20-9
- Chemical Name:
- KENPAULLONE
- Synonyms
- CS-498;KenpauL;Kenpaullon;NSC-664704;KENPAULLONE;Kenpaullone>9-BroMopaullone;NSC664704;NSC 664704;NSC-664704(Kenpaullone);Kenpaullone Kenpaullone
- CBNumber:
- CB1449240
- Molecular Formula:
- C16H11BrN2O
- Molecular Weight:
- 327.18
- MOL File:
- 142273-20-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/7/12 17:21:18
| Melting point | >300°C (dec.) |
|---|---|
| Boiling point | 613.0±45.0 °C(Predicted) |
| Density | 1.596±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 18 mg/mL, clear, yellow |
| pka | 14.29±0.20(Predicted) |
| form | Yellow-brown solid |
| color | yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| InChIKey | QQUXFYAWXPMDOE-UHFFFAOYSA-N |
| CAS DataBase Reference | 142273-20-9(CAS DataBase Reference) |
KENPAULLONE price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | K3888 | Kenpaullone ≥98% | 142273-20-9 | 1MG | ₹12221.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | K3888 | Kenpaullone ≥98% | 142273-20-9 | 5MG | ₹48755.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 422000 | Kenpaullone - CAS 142273-20-9 - Calbiochem A potent, cell-permeable, and reversible inhibitor of glycogen synthase kinase-3β (IC?? = 230 nM), Lck (IC?? = 470 nM), and cyclin-dependent kinases ( | 142273-20-9 | 1MG | ₹13100 | 2022-06-14 | Buy |
| TCI Chemicals (India) | K0052 | Kenpaullone | 142273-20-9 | 10MG | ₹8800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | K0052 | Kenpaullone | 142273-20-9 | 50MG | ₹19500 | 2022-05-26 | Buy |
KENPAULLONE Chemical Properties,Uses,Production
Chemical Properties
Tan Solid
General Description
A potent, cell-permeable, and reversible inhibitor of glycogen synthase kinase-3β (IC50 = 230 nM), Lck (IC50 = 470 nM), and cyclin-dependent kinases (Cdks). Inhibits Cdk1/cyclin B (IC50 = 400 nM), Cdk2/cyclin A (IC50 = 680 nM), Cdk2/cyclin E (IC50 = 7.5 μM), and Cdk5/p25 (IC50 = 850 nM). Also inhibits other kinases such as c-Src (IC50 = 15 μM), casein kinase II (IC50 = 20 μM), ERK1 (IC50 = 20 μM), and ERK2 (IC50 = 9 μM). Inhibition is competitive with respect to ATP binding.
Biological Activity
Potent inhibitor of CDK1/cyclin B and GSK-3 β (IC 50 values are 0.4 and 0.23 μ M respectively). Also inhibits CDK2/cyclin A, CDK2/cyclin E and CDK5/cyclin/p35 (IC 50 values are 0.68, 7.5 and 0.85 μ M respectively). Selective over c-src (IC 50 = 15 μ M), casein kinase 2 (IC 50 = 20 μ M), ERK1 (IC 50 = 20 μ M), ERK2 (IC 50 = 9 μ M) and a range of other protein kinases (IC 50 values > 35 μ M). Generates induced pluripotent stem cells (iPSCs) from somatic cells when used in combination with reprogramming factors; can replace Klf4.
KENPAULLONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29824 | 58 | Inquiry |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | China | 5738 | 58 | Inquiry |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | China | 694 | 58 | Inquiry |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | China | 13341 | 58 | Inquiry |
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