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INDIRUBIN-3'-MONOXIME

INDIRUBIN-3'-MONOXIME Structure
CAS No.
160807-49-8
Chemical Name:
INDIRUBIN-3'-MONOXIME
Synonyms
-monoxime;Indirubin-3;INDIRUBIN-3'-OXIME;Indirubine-3'-oxime;Indirubin-3'-monoxime;INDIRUBIN-3'-MONOXIME;INDIRUBIN-3’-MONOOXIME;3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one;3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one;Indirubin-3-monoxime - CAS 160807-49-8 - Calbiochem
CBNumber:
CB1325944
Molecular Formula:
C16H11N3O2
Molecular Weight:
277.28
MOL File:
160807-49-8.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

INDIRUBIN-3'-MONOXIME Properties

Melting point 247-249°C
Boiling point 532.2±50.0 °C(Predicted)
Density 1.50
storage temp. room temp
solubility DMSO: >10 mg/mL
form solid
pka 8.66±0.20(Predicted)
color Dark red or brown
Stability Light Sensitive
CAS DataBase Reference 160807-49-8

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
WGK Germany  3

INDIRUBIN-3'-MONOXIME price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) I0404 Indirubin-3′-oxime ≥98% (HPLC), solid 160807-49-8 1MG ₹12059.05 2022-06-14 Buy
Sigma-Aldrich(India) I0404 Indirubin-3′-oxime ≥98% (HPLC), solid 160807-49-8 5MG ₹54601.3 2022-06-14 Buy
Sigma-Aldrich(India) 402085 Indirubin-3ʹ-monoxime - CAS 160807-49-8 - Calbiochem A potent, reversible, and ATP-compatible inhibitor of GSK-3β (glycogen synthase kinase 3β), Cdk1 (cyclin-dependent kinase1) and Cdk5 (IC?? = 22 nM, 18 160807-49-8 1MG ₹17860 2022-06-14 Buy
Product number Packaging Price Buy
I0404 1MG ₹12059.05 Buy
I0404 5MG ₹54601.3 Buy
402085 1MG ₹17860 Buy

INDIRUBIN-3'-MONOXIME Chemical Properties,Uses,Production

Description

Indirubin-3’-oxime is a potent inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 22 nM). As GSK3β phosphorylates tau protein, indirubin-3’-oxime prevents tau phosphorylation both in vitro and in vivo at Alzheimer’s disease-relevant sites. It also inhibits cyclin-dependent kinases (CDKs) at higher concentrations, including Cdk1/cyclin B (IC50 = 180 nM), Cdk2/cyclin A (IC50 ~500 nM), Cdk2/cyclin E (IC50 = 250nM), Cdk4/cyclin D1 (IC50 = 3.3 μM) and Cdk5/p35 (IC50 = 100 nM). Indirubin-3’-oxime reversibly inhibits the proliferation of many cells types, arresting cycling in the G2/M phase.

Chemical Properties

Dark Red Solid

Uses

A potent inhibitor of GSK-3? (IC50=22nM). Also inhibits CDK1 (IC50=180nM) and CDK (IC50=100nM). It reversibly arrests asynchronous HBL-100 cells at G2. It induces apoptosis in the mammary carcinoma cell line MCF-7 (10üM).

Biological Activity

Protein kinase inhibitor: inhibits cyclin-dependent kinases (IC 50 = 0.18-3.33 μ M) and GSK-3 β (IC 50 = 0.19 μ M). Inhibits CDK5- and GSK-3 β -mediated tau phosphorylation, a process over-active in Alzheimer disease states. Also inhibits AMPK, LCK and SGK. Induces cell cycle arrest and inhibits cell proliferation.

INDIRUBIN-3'-MONOXIME Preparation Products And Raw materials

Raw materials

Preparation Products

INDIRUBIN-3'-MONOXIME Suppliers

Global( 117)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd +86-86-22-87899925 +86-8618522618860 China 694 58 Inquiry
ANHUI WITOP BIOTECH CO., LTD +8615255079626 China 23556 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. 571-88938639 +8617705817739 China 52861 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
PT CHEM GROUP LIMITED +86-85511178 +86-85511178 China 35426 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd 58
ANHUI WITOP BIOTECH CO., LTD 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
InvivoChem 58
TargetMol Chemicals Inc. 58
PT CHEM GROUP LIMITED 58

160807-49-8(INDIRUBIN-3'-MONOXIME)Related Search:

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3-[1,3-DIHYDRO-3-(HYDROXYIMINO)-2H-INDOL-2-YLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE INDIRUBIN-3'-MONOXIME INDIRUBIN-3'-OXIME Indirubine-3'-oxime INDIRUBIN-3’-MONOOXIME Indirubin-3 3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one Indirubin-3-monoxime - CAS 160807-49-8 - Calbiochem 2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro- -monoxime Indirubin-3'-monoxime 3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one 160807-49-8 Apoptosis and Cell Cycle BioChemical Cell Biology Cell Signaling and Neuroscience Cell Cycle Cell Cycle Regulators Intracellular Signaling Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes Inhibitors Protein Kinase