BORRELIDIN
- CAS No.
- 7184-60-3
- Chemical Name:
- BORRELIDIN
- Synonyms
- Aids128115;BORRELIDIN;NSC 216128;Aids-128115;BORRELIDINE;TREPONEMYCIN;Antispirochetin;Quinquangulin K 182;Quinquangulin K 031;BORRELIDIN USP/EP/BP
- CBNumber:
- CB1134351
- Molecular Formula:
- C28H43NO6
- Molecular Weight:
- 489.64
- MOL File:
- 7184-60-3.mol
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 143-145℃ |
|---|---|
| Boiling point | 584.45°C (rough estimate) |
| Density | 1.1362 (rough estimate) |
| refractive index | 1.6290 (estimate) |
| storage temp. | −20°C |
| solubility | DMSO: 1 mg/mL |
| form | White to off-white powder. |
| pka | 4.56±0.40(Predicted) |
| color | Off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | ED8750000 | |||||||||
| HS Code | 29419090 | |||||||||
| NFPA 704 |
|
BORRELIDIN Chemical Properties,Uses,Production
Uses
Borrelidin is an unusual nitrile-containing metabolite isolated from Streptomyces. Originally discovered as active against Borrelia species, borrelidin has since found a role as a selective inhibitor of bacterial and eukaryal threonyl-tRNA synthetase. More recent research has found that borrelidin is a very potent angiogenesis inhibitor and induces apoptosis of the capillary tube-forming cells. Borrelidin is an important lead for antimalarial discovery, displaying activity against drug-resistant Plasmodia.
Definition
ChEBI: A macrolide that is isolated from several Streptomyces species and displays antibiotic, antineoplastic and antimalarial properties.
General Description
Chemical structure: macrolide
BORRELIDIN Preparation Products And Raw materials
Raw materials
Cyclopentanecarboxylic acid, 2-[(2S,4E,6Z,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11, 13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]-, 2-(trimethylsilyl)ethyl ester, (1R,2R)-
1,2-Cyclopentanedicarboxylic acid, 1,2-dimethyl ester, (1R,2R)-
1-Pentanol, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,4-dimethyl-, (2S,4R)-
(1R,2R)-1,2-Cyclopentanedimethanol
1,2-Cyclopentanedicarboxylic acid, 4-oxo-, 1,2-diMethyl ester, (1R,2R)-
Preparation Products
Global( 74)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 | China | 2969 | 58 | Inquiry |
| RD International Technology Co., Limited | 18024082417 | China | 9155 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 15002134094 | China | 28118 | 58 | Inquiry |
| Guangzhou Yaoguang Technology Co., Ltd. | 13020159086 | China | 487 | 58 | Inquiry |
7184-60-3(BORRELIDIN)Related Search:
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2-(7-CYANO-8,16-DIHYDROXY-9,11,13,15-TETRAMETHYL-18-OXOOXACYCLOOCTADECA-4,6-DIEN-2-YL)-CYCLOPENTANECARBOXYLIC ACID
BORRELIDIN
BORRELIDINE
2-(7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl)cyclopentane-1-carboxylic acid
Aids128115
Aids-128115
Cyclopentanecarboxylic acid, 2-(7-cyano-8, 16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4, 6-dien-2-yl)-
Quinquangulin K 031
Quinquangulin K 182
NSC 216128
TREPONEMYCIN
TreponeMycin, U 78548, C2989
Borrelidin, froM StreptoMyces sp.
NSC 216128 Borrelidin Treponemycin
(1R,2R)-2-((2S,4E,6Z,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)cyclopentanecarboxylic acid
Borrelidin, 99%, from Streptomyces sp.
Cyclopentanecarboxylic acid, 2-[(2S,4E,6Z,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]-, (1R,2R)-
BORRELIDIN USP/EP/BP
Antispirochetin
7184-60-3
C28H43NO6
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