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RP107

RP107 Structure
CAS No.
496864-16-5
Chemical Name:
RP107
Synonyms
RP107;ALOISINE A;ALOISINE A RP107;Aloisine A, CDK inhibitor;Aloisine A - CAS 496864-16-5 - Calbiochem;4-(7-Butyl-4H-pyrrolo[2,3-b]pyrazin-6-yl)phenol;4-(7-BUTYL-5H-PYRROLO[2,3-B]PYRAZIN-6-YL)-PHENOL;Phenol, 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-;7-Butyl-6-(4-hydroxyphenyl)-5H-pyrrolo[2,3-b]pyrazine;7-N-BUTYL-6-(4-HYDROXPHENYL)[5H]PYRROLO[2,3-B]PYRAZINE
CBNumber:
CB4265483
Molecular Formula:
C16H17N3O
Molecular Weight:
267.33
MOL File:
496864-16-5.mol
MSDS File:
SDS
Modify Date:
2025/1/27 9:38:02
Request For Quotation

RP107 Properties

Melting point 281-283°C
Density 1.227
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Yellow solid
pka 9.67±0.15(Predicted)
color Light Orangish Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P305+P351+P338
Risk Statements  36/37/38
Safety Statements  26-36/37

RP107 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 128125 Aloisine A - CAS 496864-16-5 - Calbiochem A cell-permeable pyrrolo-pyrazine compound that exerts anti-proliferative effects. 496864-16-5 5MG ₹17860 2022-06-14 Buy
Product number Packaging Price Buy
128125 5MG ₹17860 Buy

RP107 Chemical Properties,Uses,Production

Chemical Properties

Yellow solid

Uses

A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25,

General Description

A cell-permeable pyrrolo-pyrazine compound that exerts anti-proliferative effects. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin-dependent kinases (Cdks; IC50 = 150 nM, 120 nM, 400 nM, and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively), glycogen synthase kinase-3 (GSK-3; IC50 = 500 nM and 1.5 μM for GSK-3α, GSK-3β, respectively), and c-Jun N-terminal kinase (JNK; IC50 = ~ 3 - 10 μM). It inhibits several other enzymes (CK1, CK2, MAPKK, PKA, PKG, PKCs, and c-raf) poorly (IC50 ≥ 100 μM). Shown to arrest cells in both G1 and G2 phases (IC50 = 7 μM and 10.5 μM for undifferentiated human teratocarcinoma cells NT2 and differentiated postmitotic neurons hNT, respectively). Shown to selectively stimulate CFTR-dependent iodide efflux in wtCFTR-CHO, Calu-3 and F508del-CFTR-CF15 cells in the presence of 1 μM Forskolin (Cat. No. 344270) with high affinity (EC50 = 150 nM, 140 nM and 111 nM, respectively).

RP107 Preparation Products And Raw materials

Raw materials

Preparation Products

RP107 Suppliers

Global( 64)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32202 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30230 58 Inquiry
Wuhan Jingkang en Biomedical Technology Co., Ltd +8613720134139 China 5221 58 Inquiry
TargetMol Chemicals Inc. +8613564774135 United States 19889 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131957 58 Inquiry
Zhengzhou Acme Chemical Co., Ltd. 0371-0371-55629727 13323845623 China 10209 58 Inquiry
Shanghai Hao Biological Technology Co., Ltd. 021-58116080 18019263206 CHINA 6906 58 Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd. 15800340161 CHINA 6650 58 Inquiry
Shanghai Yubo Biotechnology Co., Ltd. 021-51875103 15026509758 CHINA 6318 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 58
TargetMol Chemicals Inc. 58
Amadis Chemical Company Limited 58
Zhengzhou Acme Chemical Co., Ltd. 58
Shanghai Hao Biological Technology Co., Ltd. 58
Shanghai Hao Zhun Biological Technology Co., Ltd. 58
Shanghai Yubo Biotechnology Co., Ltd. 58

496864-16-5(RP107)Related Search:

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Alsterpaullone PTH-RP (107-111) (HUMAN, BOVINE, DOG, HORSE, MOUSE, RABBIT, RAT),PTH-RP (107-111) (HUMAN, RAT) PTH-RP (107-111) AMIDE (HUMAN, BOVINE, DOG, HORSE, MOUSE, RABBIT, RAT),PTH-RP (107-111) AMIDE (HUMAN, RAT) RP107 RP106
2-PHENYL-4,7-DIAZAINDOLE
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RP107 4-(7-BUTYL-5H-PYRROLO[2,3-B]PYRAZIN-6-YL)-PHENOL ALOISINE A ALOISINE A RP107 7-N-BUTYL-6-(4-HYDROXPHENYL)[5H]PYRROLO[2,3-B]PYRAZINE 7-N-BUTYL-6-(4-HYDROXYPHENYL)-[5H]PYRROLO[2,3-B]PYRAZINE RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-β]pyrazine 4-(7-Butyl-4H-pyrrolo[2,3-b]pyrazin-6-yl)phenol 7-Butyl-6-(4-hydroxyphenyl)-5H-pyrrolo[2,3-b]pyrazine Aloisine A - CAS 496864-16-5 - Calbiochem Phenol, 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)- 4-(7-butyl-1,5-dihydropyrrolo[2,3-b]pyrazin-6-ylidene)cyclohexa-2,5-dien-1-one 4-(7-butyl-l,5-dihydropyrrolo[2,3-b]pyrazin-6-ylidene)cyclohexa-2,5-dien-l-one Aloisine A, CDK inhibitor 496864-16-5 All Inhibitors Inhibitors Protein Kinase Inhibitors and Activators Aromatics Heterocycles