(S)-CR8

CAS No.: 1084893-56-0

Chemical Name:: (S)-CR8

Synonyms: CR8, (S)-Isomer;CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem;1-Butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-, (2S)-

CBNumber:: CB33152923

Molecular Formula:: C24H29N7O

Molecular Weight:: 431.53

MOL File:: 1084893-56-0.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:06

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(S)-CR8 Properties

Boiling point	671.4±65.0 °C(Predicted)
Density	1.27±0.1 g/cm3(Predicted)
storage temp.	+2C to +8C
solubility	DMSO: soluble,Ethanol: soluble
form	Off-white solid
pka	14.56±0.10(Predicted)
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

NFPA 704

	0
2		0

(S)-CR8 Chemical Properties,Uses,Production

Description

(S)-CR8 is a second generation derivative of (R)-roscovitine and an inhibitor of cyclin-dependent kinase 1 (Cdk1/cyclin B), Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T (IC₅₀s = 0.15, 0.08, 0.06, 0.12, and 0.11 μM, respectively). It also inhibits casein kinase CK1δ/ε (CKδ/ε) and DYRK1A (IC₅₀s = 0.61 and 0.9 μM, respectively). (S)-CR8 reduces cell viability in human neuroblastoma cell lines, including SH-SY5Y, SK-N-AS, SK-N-BE, and IMR32 cells (IC₅₀s = 0.43, 1.46, 0.13, and 0.14 μM, respectively). It also reduces protein levels of the survival factor Mcl-1 in SH-SY5Y cells.

(S)-CR8 Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-CR8 Suppliers

Global( 14)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32835	60	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
Suzhou Chenrui Biotechnology Co. LTD	17625585511	China	580	58	Inquiry
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	China	9806	58	Inquiry
Shanghai SuperLan Chemcial Technique Centre	021-2022843681 15618226720	China	7879	58	Inquiry
TargetMol Chemicals Inc.	4008200310	China	24648	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	3429815786 13301662590	China	9994	55	Inquiry
Changzhou Bojia Biomedical Technology Co., Ltd.	2122619822	China	18488	58	Inquiry
Riedel-de Haen AG	800 558-9160	United States	6825	87	Inquiry

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Suzhou Chenrui Biotechnology Co. LTD	58
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai SuperLan Chemcial Technique Centre	58
TargetMol Chemicals Inc.	58
ATK CHEMICAL COMPANY LIMITED	55
Changzhou Bojia Biomedical Technology Co., Ltd.	58
Riedel-de Haen AG	87

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CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem 1-Butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-, (2S)- CR8, (S)-Isomer 1084893-56-0