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Chk2 Inhibitor

Chk2 Inhibitor Structure
CAS No.
724708-21-8
Chemical Name:
Chk2 Inhibitor
Synonyms
SC203885;SC-203885;SC 203885;Chk2 Inhibitor;Chk2 Inhibitor - CAS 724708-21-8 - Calbiochem;Azepino[3,4-b]indol-1(2H)-one, 5-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydro-, (5Z)-
CBNumber:
CB82514668
Molecular Formula:
C15H13N5O2
Molecular Weight:
295.3
MOL File:
724708-21-8.mol
Modify Date:
2023/5/18 11:31:14
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Chk2 Inhibitor Properties

storage temp. -20C
solubility DMSO: Soluble
form Pale yellow solid

Chk2 Inhibitor Chemical Properties,Uses,Production

Uses

Chk2 Inhibitor is a checkpoint kinase inhibitor that mediates apoptosis and cell cycle arrest.

General Description

A cell-permeable, ATP competitive, and reversible indoloazepine compound that displays anti-proliferative and anti-inflammatory properties. Acts as a potent inhibitor of Chk2 (IC50 = 8 nM) that targets the ATP binding pocket. Exhibits selectivity for Chk2 over MEK1, Chk1, CK1δ, PKCα, PKCβII and CK2 (IC50 = 89 nM, 237 nM, 1.352 μM, 2.539 μM, 3.381 μM, and >10.0 μM, respectively). Blocks the production of IL-2 and TNF-α by preventing the transcriptional activation of NF-κB (IC50 = 3.55 μM for IL-2 production in PMA-stimulated Jurkat T cells; 8.16 μM for TNF-α production in LPS-stimulated THP-1 cells). Also reported to suppress the growth of leukemic T cells (GI50 = 1.73 μM).

Biochem/physiol Actions

Primary TargetChk2

Chk2 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

Chk2 Inhibitor Suppliers

Global( 16)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Hu Bei Jiutian Bio-medical Technology CO.,Ltd 027-88013699 17354350817 China 7432 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 China 9708 58 Inquiry
BOC Sciences 1-631-485-4226; 16314854226 United States 14059 65 Inquiry
TargetMol Chemicals Inc. 4008200310 China 24017 58 Inquiry
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 China 7984 58 Inquiry
Toronto Research Chemicals +1 (416) 665-9696 Canada 6088 71 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
TargetMol Chemicals Inc. 58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd 58
Aladdin Scientific 58
Cayman Chemical Company 81
Shanghai EFE Biological Technology Co., Ltd. 58
BOC Sciences 65
TargetMol Chemicals Inc. 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58
Toronto Research Chemicals 71

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Chk2 Inhibitor Chk2 Inhibitor - CAS 724708-21-8 - Calbiochem Azepino[3,4-b]indol-1(2H)-one, 5-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydro-, (5Z)- SC 203885 SC203885 SC-203885 724708-21-8 Cholinergics