Chk2억제제

Chk2억제제 C화학적 특성, 용도, 생산

용도

Chk2 Inhibitor is a checkpoint kinase inhibitor that mediates apoptosis and cell cycle arrest.

일반 설명

A cell-permeable, ATP competitive, and reversible indoloazepine compound that displays anti-proliferative and anti-inflammatory properties. Acts as a potent inhibitor of Chk2 (IC₅₀ = 8 nM) that targets the ATP binding pocket. Exhibits selectivity for Chk2 over MEK1, Chk1, CK1δ, PKCα, PKCβII and CK2 (IC₅₀ = 89 nM, 237 nM, 1.352 μM, 2.539 μM, 3.381 μM, and >10.0 μM, respectively). Blocks the production of IL-2 and TNF-α by preventing the transcriptional activation of NF-κB (IC₅₀ = 3.55 μM for IL-2 production in PMA-stimulated Jurkat T cells; 8.16 μM for TNF-α production in LPS-stimulated THP-1 cells). Also reported to suppress the growth of leukemic T cells (GI₅₀ = 1.73 μM).

Biochem/physiol Actions

Primary TargetChk2

Chk2억제제 준비 용품 및 원자재

원자재

준비 용품

Chk2억제제 공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd	027-88013699 17354350817	Ryan@jiutian-bio.com	China	7431	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23963	58
Shanghai Yiyan Biotechnology Co. , Ltd.	021-69985186 13611928337	3427709316@qq.com	China	7980	58

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