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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >PI3K inhibitor >2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone

2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone

2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone Structure
CAS No.
371242-69-2
Chemical Name:
2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
Synonyms
CS-428;IC-87114;IC-87114 100MG;IC-87114, >=98%;IC-87114 (PIK-293);IC-87114 (IC87114);IC-87114;IC87114;IC 87114;IC87114 (PI3-K delta inhibitor);2-((6-AMINO-9H-PURIN-9-YL)METHYL)-5-METHYL-3-O-TOLYLQUINAZOLIN-4(3H)-ONE;2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
CBNumber:
CB12485097
Molecular Formula:
C22H19N7O
Molecular Weight:
397.43
MOL File:
371242-69-2.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:00
Request For Quotation

2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone Properties

Boiling point 673.7±65.0 °C(Predicted)
Density 1.43
storage temp. Store at -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥6.62 mg/mL in DMF
form White powder solid.
pka 3.90±0.10(Predicted)
color White to gray
CAS DataBase Reference 371242-69-2

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone Chemical Properties,Uses,Production

Description

The phosphatidylinositol 3-kinase (PI3K) signaling pathway has central roles in cell growth, development, and survival. IC-87114 is a cell-permeable selective inhibitor of the PI3K catalytic subunit p110δ (IC50 = 0.5 μM). It less effectively inhibits p110γ and p110β (IC50 = 29 and 75 μM, respectively) and has no significant effect on p110α and several other kinases. This product is used to elucidate the role of p110δ in cells, including neutrophils, natural killer cells, and other types of leukocytes. It has also been used in mice.

Uses

IC 87114 is a selective PI3Kδ inhibitor.

Definition

ChEBI: A member of the class of quinazolines that is quinazolin-4(3H)-one carrying (6-amino-9H-purin-9-yl)methyl, 2-methylphenyl and methyl substituents at positions 2, 3 and 5 respectively.

2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone Preparation Products And Raw materials

Raw materials

Preparation Products

2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone Suppliers

Global( 129)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26216 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. 571-88938639 +8617705817739 China 52861 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Capot Chemical Co.,Ltd. 60
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58

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2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone IC-87114 IC-87114 (IC87114) 4(3H)-Quinazolinone, 2-[(6-aMino-9H-purin-9-yl)Methyl]-5-Methyl-3-(2-Methylphenyl)- IC87114 (PI3-K delta inhibitor) 2-((6-AMINO-9H-PURIN-9-YL)METHYL)-5-METHYL-3-O-TOLYLQUINAZOLIN-4(3H)-ONE 2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone IC-87114 IC-87114 (PIK-293) IC-87114;IC87114;IC 87114 IC-87114 100MG IC-87114, >=98% CS-428 2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone USP/EP/BP 371242-69-2 C22H19N7O Inhibitors Akt mTOR PI3K