ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >PI3K inhibitor >VS-5584

VS-5584

CAS No.: 1246560-33-7

Chemical Name:: VS-5584

Synonyms: SB-2343;VS-5584 (SB2343);SB2343;CS-875;SB 2343;VS-5584;VS-5584, >=98%;VS-5584 VS5584;VS-5584 USP/EP/BP;VS-5584 (SB2343);VS-5584;VS5584;VS 5584

CBNumber:: CB42666411

Molecular Formula:: C17H22N8O

Molecular Weight:: 354.41

MOL File:: 1246560-33-7.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:08

Request For Quotation

VS-5584 Properties

Boiling point	687.2±65.0 °C(Predicted)
Density	1.48±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	insoluble in H2O; ≥17.7 mg/mL in DMSO; ≥4.71 mg/mL in EtOH with ultrasonic
form	solid
pka	4.53±0.10(Predicted)
color	Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08,GHS09
Signal word	Danger
Hazard statements	H302-H410-H372
Precautionary statements	P260-P264-P273-P501

VS-5584 Chemical Properties,Uses,Production

Description

Phosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. VS-5584 is a purine analog that inhibits mTOR (IC₅₀ = 37 nM) and PI3K (IC₅₀s = 16, 68, 25, and 42 nM for the α, β, γ, and δ isoforms, respectively) without relevant activity against more than 400 additional lipid and protein kinases. By inhibiting the phosphorylation of substrates downstream of PI3K and mTOR, VS-5584 demonstrates broad anti-proliferative sensitivity leading to tumor growth inhibition in human tumor models.

VS-5584 Preparation Products And Raw materials

Raw materials

DIMETHYLZINC

Preparation Products

VS-5584 Suppliers

Global( 96)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29901	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	26216	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
LEAPCHEM CO., LTD.	58

VS-5584 Spectrum

VS-5584(1246560-33-7)¹HNMR

1246560-33-7(VS-5584)Related Search:

VX-745 USP/EP/BP VX 702 Vps VR23 VRT752271

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XL147

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2-Pyrimidinamine, 5-[8-methyl-9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]- 5-[8-Methyl-9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]-2-pyrimidinamine VS-5584 VS-5584, >=98% VS-5584 SB 2343 SB2343 5-(9-Isopropyl-8-Methyl-2-Morpholin-4-yl-9H-purin-6-yl)-pyriMidin-2-ylaMine 5-(9-ISOPROPYL-8-METHYL-2-MORPHOLINO-9H-PURIN-6-YL)PYRIMIDIN-2-AMINE 5-[8-Methyl-9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]-2-pyrimidinamine VS-5584 (SB2343);VS-5584;VS5584;VS 5584 SB-2343; VS5584; VS 5584; SB2343; SB 2343 CS-875 5-[9-Isopropyl-8-methyl-2-(morpholin-4-yl)purin-6-yl]pyrimidin-2-amine VS-5584 USP/EP/BP SB-2343 VS-5584 (SB2343) VS-5584 VS5584 1246560-33-7 C17H22N8O Akt mTOR PI3K PI3K/Akt/mTOR Inhibitors