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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Angiogenesis >FAK inhibitors >Defactinib

Defactinib

Defactinib Structure
CAS No.
1073154-85-4
Chemical Name:
Defactinib
Synonyms
VS6063;VS-6063;VS 6063;CS-1796;Defactinib;Defactinib (VS-6063;Defactinib free base;VS-6063; PF-04554878;PF-04554878 Defactinib;Defactinib(PF-04554878)
CBNumber:
CB82716190
Molecular Formula:
C20H21F3N8O3S
Molecular Weight:
510.49
MOL File:
1073154-85-4.mol
Modify Date:
2023/6/30 15:45:59
Request For Quotation

Defactinib Properties

Density 1.495±0.06 g/cm3(Predicted)
storage temp. -20°C (des.)
solubility Soluble in DMSO (up to at least 25mg/ml)
pka 15.16±0.46(Predicted)
form solid
color White
Stability Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
NFPA 704
0
2 0

Defactinib Chemical Properties,Uses,Production

Description

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays a vital role in many oncogenic pathways. Defactinib is a dose-dependent inhibitor of FAK, with maximal inhibition of FAK autophosphorylation in cells achieved at 10 μM. It is less effective against the related kinase PYK2. Defactinib restores the chemosensitivity of taxane-resistant cells to paclitaxel , although it is not cytotoxic alone. Defactinib decreases YB-1 phosphorylation and nuclear accumulation in an Akt-dependent manner. It is orally bioavailable, inhibiting FAK and augmenting paclitaxel action in suppressing the growth and number of ovarian cancer cell tumors in mice.

Uses

Defactinib is a selective and orally active FAK inhibitor phase 2. Used in treating cancer patients as it decreases proliferation and increases apoptosis.

Defactinib Preparation Products And Raw materials

Raw materials

Preparation Products

Defactinib Suppliers

Global( 119)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
FDC Limited 0240 - 2554407 / 2554299 / 2554967 New Delhi, India 88 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
FDC Limited 58
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
career henan chemical co 58
TargetMol Chemicals Inc. 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
LEAP CHEM CO., LTD. 58

Defactinib Spectrum

Defactinib(1073154-85-4)1HNMR

1073154-85-4(Defactinib)Related Search:

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Defactinib VS 6063 VS-6063 Defactinib(PF-04554878) N-methyl-4-(4-((3-(N-methylmethan-3-ylsulfonamido)pyrazin-2-yl)methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzamide N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide N-METHYL-4-(4-((3-(N-METHYLMETHYL SULFON N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide Defactinib(PF-04554878)(VS-6063) Defactinib free base Benzamide, N-methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]- CS-1796 VS-6063; VS6063; VS 6063; PF04554878; PF-04554878; PF 04554878 PF-04554878 Defactinib VS-6063; PF-04554878 N-methyl-4-(4-((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzamide Defactinib (VS-6063 VS6063 1073154-85-4 C20H21F3N8O3S Inhibitors API