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ODM-201

ODM-201 Structure
CAS No.
1297538-32-9
Chemical Name:
ODM-201
Synonyms
Darolutamide;BAY-1841788;0DM021;ODM 021;ODM-201;CS-1565;ODM-021;Darolutamid;Darrolumide;Darolutamide D4
CBNumber:
CB43052901
Molecular Formula:
C19H19ClN6O2
Molecular Weight:
398.85
MOL File:
1297538-32-9.mol
Modify Date:
2024/3/27 16:59:26
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ODM-201 Properties

Melting point 169 - 171°C
Boiling point 719.5±60.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
pka 11.10±0.10(Predicted)
form Solid
color White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H410-H302-H400
Precautionary statements  P264-P270-P301+P312-P330-P501-P273-P391-P501-P273-P391-P501
NFPA 704
0
2 0

ODM-201 Chemical Properties,Uses,Production

Description

ODM-201 is a novel androgen receptor (AR) inhibit designed to inhibit the growth of prostate cancer cells through binding to the AR to inhibit the testosterone-induced AR nuclear translocation. It is particularly used in patients with progressive metastatic castration-resistant prostate cancer. It is effective in inhibiting the activity of some mutant ARs emerging during antiandrogen therapies, including the F876L mutation version which is resistant to enzalutamide and ARN-509 (the second-generation antiandrogens).Therefore, it has potential to overcome the resistance issue occurring upon AR-targeted therapies.

Uses

ODM-201 is a compound being used as a novel next-generation androgen receptor-directed therapy for prostate cancer.

References

Moilanen, Anu Maarit, et al. "Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies." Sci Rep 5.2(2015):12007. Fizazi, Karim, et al. "ODM-201, a new generation androgen receptor inhibitor for castration-resistant prostate cancer: Preclinical and phase I data." Genitourinary Cancers Symposium of the Conquer-Cancer-Foundation of 2013. Fizazi, K, et al. "Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial." Lancet Oncology 5.9(2014):975-85.

ODM-201 Preparation Products And Raw materials

Raw materials

4-Acetyl-2-chlorobenzonitrile (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chlorobenzonitrile 5-(1-Hydroxyethyl)-1H-pyrazole-3-carboxylic acid 2-chloro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzonitrile 2-Chloro-4-(1H-Pyrazol-5-Yl)Benzonitrile
ORM-15341 4-Bromo-2-chlorobenzonitrile
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Preparation Products

ODM-201 Suppliers

Global( 190)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Venkatasai Life Sciences +91-9908134868 +91-8008303069 Hyderabad, India 186 58 Inquiry
Vijaya Pharma And Life Science +91-8939866271 +91-8939866271 Tamil Nadu, India 320 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Henan Bao Enluo International TradeCo.，LTD +86-17331933971 +86-17331933971 China 2503 58 Inquiry
Hebei Kangcang new material Technology Co., LTD +8615713292910 China 341 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21669 55 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9337 55 Inquiry
Supplier Advantage
Venkatasai Life Sciences 58
Vijaya Pharma And Life Science 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
Pharma Affiliates 58
Henan Bao Enluo International TradeCo.，LTD 58
Hebei Kangcang new material Technology Co., LTD 58
Henan Tianfu Chemical Co.,Ltd. 55
Hangzhou FandaChem Co.,Ltd. 55

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1297538-32-9(ODM-201)Related Search:

ODM203 Defactinib PF 04554878 hydrochloride
ODM-201 N-[(1S)-2-[3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide N-((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide Darolutamide (ODM-201) ODM-201(BAY-1841788) CS-1565 ODM-201(Darolutamide) N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)-1-hydroxyethyl]-1H-pyrazole-3-carboxamide 0DM021 BAY-1841788;ODM-021;0DM021;ODM 021 ODM 021 ODM-021 DAROLUTAMIDE;BAY-1841788 1H-Pyrazole-3-carboxamide, N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)- Darolutamid Darolutamide D4 N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)Chemicalbook-1-hydroxyethyl]-1H-pyrazole-3-carboxamide TIANFUCHEM--1297538-32-9---ODM-201 BAY-1841788 Darolutamide N-[(2S)-1-[3-(3-chloro-4-cyanophenyl)pyrazol-1-yl]propan-2-yl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide N-((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-3-(1-hydroxyethyl)-1H-pyrazole-5-carboxamide Dantrolene Impurity 6 Darolutamide, ODM-201,BAY-1841788 Darrolumide 1297538-32-9 C19H19ClN6O2 API