NSC 23766 TETRAHYDROCHLORIDE
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- Product name: NSC 23766 TETRAHYDROCHLORIDE
- CAS: 733767-34-5
- MF: C24H35N7
- MW: 421.58
- EINECS:
- MDL Number:MFCD07848572
- Synonyms:NSC 23766 TETRAHYDROCHLORIDE;N6-[2-[[4-(DIETHYLAMINO)-1-METHYLBUTYL]AMINO]-6-METHYL-4-PYRIMIDINYL]-2-METHYL-4,6-QUINOLINEDIAMINE TRIHYDROCHLORIDE;NSC 23766;N6-[2-(4-Diethylamino-1-methylbutylamino)-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine tetrahydrochloride;N6-(2-(5-(Diethylamino)pentan-2-ylamino)-6-methylpyrimidin-4-yl)-2-methylquinoline-4,6-diamine;NSC23766;NSC 23766;CS-1187;CS-594
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Properties
storage temp. :Desiccate at RT
solubility :Soluble in DMSO (50 mg/ml); Water (50 mg/ml)
form :White powder solid.
color :White
Water Solubility :Soluble in water.
Sensitive :Light Sensitive & Hygroscopic
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
solubility :Soluble in DMSO (50 mg/ml); Water (50 mg/ml)
form :White powder solid.
color :White
Water Solubility :Soluble in water.
Sensitive :Light Sensitive & Hygroscopic
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Safety Information
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Description
The compound blocks activation by the guanine nucleotide exchange factors Trio and Tiam1, but does not affect interactions with RhoA or Cdc42. NSC23766 blocks ADP-mediated platelet aggregation. Inhibition of Rac1 by NSC23766 restores sensitivity to trastuzumab by restoring down-regulation of ErbB2. Membrane type 1-matrix metalloproteinases (MT-1MMP) expression in CB CD34+ cells has been reported to decrease in the presence of NSC 23766. Silveta compress investigations indicate that NSC 23766 depolarizes endomembrane cycling, altered polar adhesive secretion, and tip growth.More related product prices
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Suppliers and manufacturers
InvivoChem
Coresyn Pharmatech Co., Ltd.
Aladdin Scientific
Amadis Chemical Company Limited
Beijing Anbiqi Biotechnology Co., Ltd.
Shanghai Shanran Biotechnology Co., Ltd.
Wuhan Boot Biotechnology Co., Ltd.
Shanghai Han-Xiang Chemical Co., Ltd.
Shanghai Yuda Industrial Co., Ltd.
Shanghai Chaoyan Biotechnology Co., Ltd.