NSC-348884
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- Product name: NSC-348884
- CAS: 81624-55-7
- MF: C38H40N10
- MW: 636.79
- EINECS:
- MDL Number:MFCD12546137
- Synonyms:NSC-348884;N1,N1,N2,N2-Tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine;1,2-EthanediaMine, N,N,N',N'-tetrakis[(5-Methyl-1H-benziMidazol-2-yl)Methyl]- (9CI);CS-2168;NSC348884;NSC-348884;NSC 348884;1,2-Ethanediamine, N1,N1,N2,N2-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-;lymphoma,cancer,inhibit,SKOV3,MOSEC/Luc cell,NSC-348884,NSC 348884,LNCaP,doxorubicin,NSC348884,Inhibitor,ES2,small molecular,p53,Apoptosis;NSC 348884/NSC348884
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Properties
Boiling point :1001.7±65.0 °C(Predicted)
Density :1.347
storage temp. :under inert gas (nitrogen or Argon) at 2-8°C
solubility :≥63.7 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :solid
pka :11.61±0.10(Predicted)
color :Light yellow to yellow
Density :1.347
storage temp. :under inert gas (nitrogen or Argon) at 2-8°C
solubility :≥63.7 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :solid
pka :11.61±0.10(Predicted)
color :Light yellow to yellow
Safety Information
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Description
Nucleophosmin is a nucleolar phosphoprotein involved in cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, centrosome duplication, and molecular chaperoning. Its activity is dependent on oligomerization at its N-terminal domain, and it is abundantly expressed in tumor and developing cells where it serves to inhibit both cellular differentiation and apoptosis. NSC 348884 is a small molecule that inhibits the formation of nucleophosmin dimers by disrupting a required binding pocket. It can inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 μM.More related product prices
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