NSC632839hydrochloride
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- ₹11160.58
- Product name: NSC632839hydrochloride
- CAS: 157654-67-6
- MF: C21H21NO.ClH
- MW: 339.864
- EINECS:604-604-1
- MDL Number:MFCD09753281
- Synonyms:Ubiquitin Isopeptidase Inhibitor II, F6;NSC 632839;4-Piperidione,3,5-bis[(4-methylphenyl)methylene] hydrochloride;NSC632839hydrochloride;3,5-Bis[(4-methylphenyl)methylene]-4-piperidonehydrochloride;NSC 632839;NSC-632839;Ubiquitin Isopeptidase Inhibitor II;NSC632839 HCl
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0270
- Product descriptionNSC 632839 ≥98% (HPLC)
- Packaging5MG
- Price₹11160.58
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0270 | NSC 632839 ≥98% (HPLC) | 5MG | ₹11160.58 | 2022-06-14 | Buy |
Properties
storage temp. :Store at +4°C
solubility :DMSO: ≥2mg/mL (warmed)
form :powder
color :faint yellow to dark yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
solubility :DMSO: ≥2mg/mL (warmed)
form :powder
color :faint yellow to dark yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into various groups, the largest being the ubiquitin-specific proteases (USPs). NSC 632839 inhibits USP2 and USP7 as well as the ubiquitin-like SUMO peptidase SENP2 with EC50 values of 45, 37, and 9.8 μM, respectively. It is reported to inhibit apoptosis through a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 = 15.7 μM in cells sensitized by E1A, an adenoviral oncogene).More related product prices
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