Pifithrin-μ
|
- ₹6800 - ₹39069
- Product name: Pifithrin-μ
- CAS: 64984-31-2
- MF: C8H7NO2S
- MW: 181.21
- EINECS:
- MDL Number:MFCD00181531
- Synonyms:PHENYLETHYNSULFONIC ACID AMIDE;Pifithrin--;Phenyl-ethynesulfonic Acid Amide;Pifithrin-u;2-Phenylethynesulfonamide, PFTμ;EthynesulfonaMide, 2-phenyl-;NSC 303580;Pftmu
7 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
- ottokemi
Package
- 5MG
- 10MG
- 100MG
- ManufacturerTCI Chemicals (India)
- Product numberP2048
- Product descriptionPifithrin-μ
- Packaging10MG
- Price₹6800
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberP2048
- Product descriptionPifithrin-μ
- Packaging100MG
- Price₹13100
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberP0122
- Product descriptionPifithrin-μ ≥97% (HPLC), solid
- Packaging5MG
- Price₹9580.13
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number506155
- Product descriptionPifithrin-μ - CAS 64984-31-2 - Calbiochem A cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria wit
- Packaging10MG
- Price₹11880.01
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberP0122
- Product descriptionPifithrin-μ ≥97% (HPLC), solid
- Packaging10MG
- Price₹17731.35
- Updated2022-06-14
- Buy
- Manufacturerottokemi
- Product number P 7299
- Product descriptionPifithrin-μ, ≥97% (HPLC)
- Packaging5mg
- Price₹19089
- Updated2022-05-26
- Buy
- Manufacturerottokemi
- Product number P 7299
- Product descriptionPifithrin-μ, ≥97% (HPLC)
- Packaging10mg
- Price₹39069
- Updated2022-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | P2048 | Pifithrin-μ | 10MG | ₹6800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P2048 | Pifithrin-μ | 100MG | ₹13100 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | P0122 | Pifithrin-μ ≥97% (HPLC), solid | 5MG | ₹9580.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 506155 | Pifithrin-μ - CAS 64984-31-2 - Calbiochem A cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria wit | 10MG | ₹11880.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P0122 | Pifithrin-μ ≥97% (HPLC), solid | 10MG | ₹17731.35 | 2022-06-14 | Buy |
| ottokemi | P 7299 | Pifithrin-μ, ≥97% (HPLC) | 5mg | ₹19089 | 2022-05-26 | Buy |
| ottokemi | P 7299 | Pifithrin-μ, ≥97% (HPLC) | 10mg | ₹39069 | 2022-05-26 | Buy |
Properties
Melting point :135.0 to 139.0 °C
Boiling point :351.7±25.0 °C(Predicted)
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble >10mg/mL, clear
pka :7.96±0.60(Predicted)
form :solid
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :ZZUZYEMRHCMVTB-UHFFFAOYSA-N
Boiling point :351.7±25.0 °C(Predicted)
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble >10mg/mL, clear
pka :7.96±0.60(Predicted)
form :solid
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :ZZUZYEMRHCMVTB-UHFFFAOYSA-N
Safety Information
| Symbol(GHS): |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
In addition to its transactivational functions, p53 mediates apoptosis by binding with the anti-apoptotic proteins Bcl-xL and Bcl-2 at the mitochondrial surface. Pifithrin-μ (PFT-μ) is an inhibitor of p53-mediated apoptosis, preventing p53 binding to Bcl-xL and Bcl-2 at the mitochondria without affecting p53 transactivational activities In vitro, PFT-μ binds both p53 (Kd = 0.82 mM) and Bcl-xL (Kd = 0.80 mM). PFT-μ reduces p53-mediated apoptosis induced by γ-radiation in mouse thymocytes in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. At 25 μM, PFT-μ reduces apoptosis triggered by nutlin-3, which inhibits MDM2/p53 binding and potentiates p53-mediated growth arrest and apoptosis. PFT-μ also interacts selectively with heat shock protein 70 (HSP70), leading to disruption of the association between HSP70 and many of its co-chaperones and substrate proteins.More related product prices
(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride 110-30-5 1,9-Pyrazoloanthrone Pifithrin-α (PFTα) NSC 247030 HAMNO NSC23005 Sodium NSC632839hydrochloride NSC228155 S3I-201 5-(4-iodobenzylidene)rhodanine 1,3-Bis(4-aminophenyl)urea 2-Pyridinecarbothioamide, N-2-pyridinyl- SB 203580 AZD8931 Erlotinib hydrochloride 79606-45-4 NSC781406 TIMTEC-BB SBB006342 4-Chloro-N,N-di-n-propylbenzaMide, 97%Related product price
- 110-30-5
₹1800-20010 - 1,9-Pyrazoloanthrone
₹6100-60295.25 - Pifithrin-α (PFTα)
₹4800-23340
