NSC781406
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- Product name: NSC781406
- CAS: 1676893-24-5
- MF: C29H27F2N5O5S2
- MW: 627.68
- EINECS:
- MDL Number:
- Synonyms:NSC781406;NSC781406;NSC-781406;NSC 781406;NSC-781406;NSC 781406;Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-[3-[4-(methylsulfonyl)-1-piperazinyl]-1-propyn-1-yl]-6-quinolinyl]-3-pyridinyl]-;NSC781406,Phosphoinositide 3-kinase,NSC 781406,NSC-781406,PI3K,Mammalian target of Rapamycin,Inhibitor,inhibit,mTOR
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Properties
Boiling point :775.1±70.0 °C(Predicted)
Density :1.52±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 10mg/mL; DMSO: 20mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL
form :A solid
pka :6.23±0.40(Predicted)
color :White to off-white
Density :1.52±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 10mg/mL; DMSO: 20mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL
form :A solid
pka :6.23±0.40(Predicted)
color :White to off-white
Safety Information
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Description
NSC 781406 is a dual inhibitor of PI3K and mammalian target of rapamycin (mTOR; IC50s = 2.0, 9.4, 2.7, 14, and 5.4 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR, respectively). It inhibits cell growth in the NCI-60 panel of cancer cell lines (mean GI50 = 65 nM). NSC 781406 (30 mg/kg) reduces tumor volume in a BEL-7404 hepatic cancer mouse xenograft model.More related product prices
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