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NSC 42834

NSC 42834 Structure
  • ₹0
  • Product name: NSC 42834
  • CAS: 195371-52-9
  • MF: C23H24N2O
  • MW: 344.45
  • EINECS:
  • MDL Number:MFCD00023550
  • Synonyms:JAK2 Inhibitor V, Z3;NSC 42834;1-Butanone, 2-Methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]-;2-METHYL-1-PHENYL-4-(PYRIDIN-2-YL)-2-(2-(PYRIDIN-2-YL)ETHYL)BUTAN-1-ONE;2-Methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]-1-butanone;NSC 42834 2-Methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]-1-butanone;JAK2 Inhibitor V, Z3, >=98%;JAK2 Inhibitor V
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :520.4±50.0 °C(Predicted)
Density :1.106±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
form :Powder
pka :5.90±0.12(Predicted)
color :Colorless to light yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 in which a switch from valine to phenylalanine occurs at the 617 position (V617F). JAK2 Inhibitor V is an inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2, displaying IC50 values between 10 and 30 μM. It has no effect on Tyk2 or c-Src kinase function. JAK2 Inhibitor V blocks the proliferation of erythroleukemia cells and human hematopoietic progenitor cells expressing JAK2-V617F.

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Related product price

Suppliers and manufacturers

career henan chemical co
2-METHYL-1-PHENYL-4-(PYRIDIN-2-YL)-2-(2-(PYRIDIN-2-YL)ETHYL)BUTAN-1-ONE
₹1.00 /1ASSAYS
2-METHYL-1-PHENYL-4-(PYRIDIN-2-YL)-2-(2-(PYRIDIN-2-YL)ETHYL)BUTAN-1-ONE CAS:195371-52-9
A.J Chemicals
ATK CHEMICAL COMPANY LIMITED
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Aladdin Scientific
Amadis Chemical Company Limited ShangHai Siyan Biological Technology Co., Ltd.