b-AP15
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- ₹17860
- Product name: b-AP15
- CAS: 1009817-63-3
- MF: C22H17N3O6
- MW: 419.39
- EINECS:
- MDL Number:MFCD26142662
- Synonyms:b-AP15 (NSC687852);4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-, (3E,5E)-;NSC 687852 (b-AP15);LM-3077;(3E,5E)-3,5-Bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-4-piperidinone;(3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one;(3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)-4-piperidinone;(3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 10MG
- ManufacturerSigma-Aldrich(India)
- Product number662140
- Product descriptionDUB Inhibitor IV, b-AP15 - CAS 1009817-63-4 - Calbiochem The DUB Inhibitor IV, b-AP15 controls the biological activity of DUB. This small molecule/inhibitor is primarily used for Protease Inhibitors applicat
- Packaging10MG
- Price₹17860
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 662140 | DUB Inhibitor IV, b-AP15 - CAS 1009817-63-4 - Calbiochem The DUB Inhibitor IV, b-AP15 controls the biological activity of DUB. This small molecule/inhibitor is primarily used for Protease Inhibitors applicat | 10MG | ₹17860 | 2022-06-14 | Buy |
Properties
Boiling point :670.4±55.0 °C(Predicted)
Density :1.416±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 35 mg/ml).
form :solid
pka :-1.58±0.20(Predicted)
color :Pale yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Density :1.416±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 35 mg/ml).
form :solid
pka :-1.58±0.20(Predicted)
color :Pale yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Proteasome-associated deubiquitinases (DUBs) release ubiquitin from proteasome-targeted ubiquitinated proteins, regenerating free ubiquitin. b-AP15 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs. It inhibits DUB activity in purified 19S proteasomes with an IC50 value of 2.1 μM. It exhibits little or no activity against several other DUBs. Through its effects on USP14 and UCHL5, b-AP15 blocks tumor progression in vivo in mice and prevents organ infiltration in mouse models of myeloid leukemia. b-AP15 also renders tumor cells sensitive to TNF-mediated apoptosis by natural killer and T cells.More related product prices
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