NSC5844
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- Product name: NSC5844
- CAS: 140926-75-6
- MF: C20H16Cl2N4
- MW: 383.27
- EINECS:
- MDL Number:MFCD29924743
- Synonyms:NSC5844;N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine;1,2-Ethanediamine, N1,N2-bis(7-chloro-4-quinolinyl)-;RE-640;RE640;RE 640;NSC 5844; NSC-5844; RE 640; RE-640; RE640;NSC5844 (RE640)
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Properties
Boiling point :632.6±55.0 °C(Predicted)
Density :1.431±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 0.33 mg/ml; DMSO: 0.25 mg/ml; Ethanol: slightly soluble
form :A crystalline solid
pka :6.61±0.50(Predicted)
color :White to off-white
Density :1.431±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 0.33 mg/ml; DMSO: 0.25 mg/ml; Ethanol: slightly soluble
form :A crystalline solid
pka :6.61±0.50(Predicted)
color :White to off-white
Safety Information
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Description
NSC 5844 is a bis-quinoline with diverse biological activities. It inhibits the growth of P. falciparum strains that are sensitive (D-6) and resistant (W-2) to chloroquine in vitro (IC50s = 17 and 27 nM, respectively) but lacks activity against P. berghei in vivo. NSC 5844 inhibits the growth of MDA-MB-468 and MCF-7 breast cancer cells with GI50 values of 7.35 and 14.80 μM, respectively. It also inhibits 24% of botulinum neurotoxin serotype A light chain (BoNT/A LC) metalloprotease activity at a concentration of 20 μM.More related product prices
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