Chk2 Inhibitor
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- Product name: Chk2 Inhibitor
- CAS: 724708-21-8
- MF: C15H13N5O2
- MW: 295.3
- EINECS:-0
- MDL Number:MFCD22380609
- Synonyms:Chk2 Inhibitor;Chk2 Inhibitor - CAS 724708-21-8 - Calbiochem;Azepino[3,4-b]indol-1(2H)-one, 5-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydro-, (5Z)-;SC 203885;SC203885;SC-203885
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Properties
storage temp. :-20C
solubility :DMSO: Soluble
form :Pale yellow solid
solubility :DMSO: Soluble
form :Pale yellow solid
Safety Information
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Description
Chk2 Inhibitor is an indoloazepine checkpoint kinase inhibitor that mediates apoptosis and cell cycle arrest. Checkpoint kinase 2 is activated upon DNA damage or genomic instability which eventually causes apoptosis. Mechanistic studies show that Chk2 inhibitor causes autophosphorylation of Chk2 at Thr68 and targets ATP binding pockets of Chk2. Further studies demonstrate that Chk2 inhibitors also inhibit Chk1 and MEK-1 and affect interleukin-2 (IL-2), TNF-α, MEK-1, and GSK-3β.More related product prices
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