LY2811376
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- ₹0
- Product name: LY2811376
- CAS: 1194044-20-6
- MF: C15H14F2N4S
- MW: 320.36
- EINECS:-0
- MDL Number:MFCD18074525
- Synonyms:LY2811376;(4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine;LY 2811376,(4S)-4-[2,4-Difluoro-5-(5-pyriMidinyl)phenyl]-5,6-dihydro-4-Methyl-4H-1,3-thiazin-2-aMine;(S)-4-(2,4-difluoro-5-(pyriMidin-5-yl)phenyl)-4-Methyl-5,6-dihydro-4H-1,3-thiazin-2-aMine;(4S)-4-(2,4-difluoro-5-pyriMidin-5-ylphenyl)-4-Methyl-5,6-dihydro-1,3-thiazin-2-aMine;N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride Tubastatin A HCl LY2811376;LY2811376, >=98%;CS-1893
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Boiling point :486.5±55.0 °C(Predicted)
Density :1.42
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :crystalline solid
pka :5.60±0.40(Predicted)
color :White to khaki
Density :1.42
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :crystalline solid
pka :5.60±0.40(Predicted)
color :White to khaki
Safety Information
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Description
Accumulation of the β-amyloid (Aβ) peptide in the brain is implicated as the primary cause of neurodegeneration and progression of Alzheimer’s disease. Aβ is derived from sequential proteolytic cleavage of the amyloid precursor protein (APP) by β-secretase (BACE) and γ-secretase. LY2811376 is a non-peptide inhibitor of BACE1 (IC50 = 239 nM for the synthetic peptide) that demonstrates ~10-fold selectivity over BACE2 and >50-fold selectivity over the aspartyl proteases cathepsin D, pepsin, and renin. LY2811376 treatment in APP-overexpressing cells and transgenic animal models yields a dose-dependent decrease in Aβ. Furthermore, LY2811376 has been reported to reduce C99 and sAPPβ, the two primary APP cleavage products generated by BACE1.More related product prices
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Suppliers and manufacturers
PNP Biotech Co. Ltd
CLEARSYNTH LABS LTD.
A.J Chemicals
Capot Chemical Co.,Ltd.
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
TargetMol Chemicals Inc.
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
₹0.00 /25kg
(4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine CAS:1194044-20-6
(4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine CAS:1194044-20-6