LY-364947
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- ₹18694.78 - ₹1611522.08
- Product name: LY-364947
- CAS: 396129-53-6
- MF: C17H12N4
- MW: 272.3
- EINECS:
- MDL Number:MFCD00800758
- Synonyms:LY 364947 4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]quinoline;LY-364947, 396129-53-6;Transforming Growth Factor-β Type I Receptor Kinase Inhibitor;LY-364947;LY-364947, >=98%;LY364947;HTS466284; LY-364947;TGF-β RI Kinase Inhibitor ;[3-(Pyridin-2-yl)-4-(4-quinonyl)]-1H-pyrazole
6 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 616451-10MG
- 616451-5UNMG
- 5MG
- 616451-100MG
- 616451-5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberL6293
- Product descriptionLY-364947 ≥98% (HPLC)
- Packaging5MG
- Price₹18694.78
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number616451-M
- Product descriptionTGF-β RI Kinase Inhibitor - CAS 396129-53-6 - Calbiochem The TGF-β RI Kinase Inhibitor, also referenced under CAS 396129-53-6, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibit
- Packaging616451-5MG
- Price₹19050
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberL6293
- Product descriptionLY-364947 ≥98% (HPLC)
- Packaging25MG
- Price₹74735.8
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number616451-M
- Product descriptionTGF-β RI Kinase Inhibitor - CAS 396129-53-6 - Calbiochem The TGF-β RI Kinase Inhibitor, also referenced under CAS 396129-53-6, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibit
- Packaging616451-100MG
- Price₹194953.92
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number616451-M
- Product descriptionTGF-β RI Kinase Inhibitor - CAS 396129-53-6 - Calbiochem The TGF-β RI Kinase Inhibitor, also referenced under CAS 396129-53-6, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibit
- Packaging616451-10MG
- Price₹1611522.08
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number616451-M
- Product descriptionTGF-β RI Kinase Inhibitor - CAS 396129-53-6 - Calbiochem The TGF-β RI Kinase Inhibitor, also referenced under CAS 396129-53-6, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibit
- Packaging616451-5UNMG
- Price₹1611522.08
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | L6293 | LY-364947 ≥98% (HPLC) | 5MG | ₹18694.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 616451-M | TGF-β RI Kinase Inhibitor - CAS 396129-53-6 - Calbiochem The TGF-β RI Kinase Inhibitor, also referenced under CAS 396129-53-6, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibit | 616451-5MG | ₹19050 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L6293 | LY-364947 ≥98% (HPLC) | 25MG | ₹74735.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 616451-M | TGF-β RI Kinase Inhibitor - CAS 396129-53-6 - Calbiochem The TGF-β RI Kinase Inhibitor, also referenced under CAS 396129-53-6, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibit | 616451-100MG | ₹194953.92 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 616451-M | TGF-β RI Kinase Inhibitor - CAS 396129-53-6 - Calbiochem The TGF-β RI Kinase Inhibitor, also referenced under CAS 396129-53-6, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibit | 616451-10MG | ₹1611522.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 616451-M | TGF-β RI Kinase Inhibitor - CAS 396129-53-6 - Calbiochem The TGF-β RI Kinase Inhibitor, also referenced under CAS 396129-53-6, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibit | 616451-5UNMG | ₹1611522.08 | 2022-06-14 | Buy |
Properties
Melting point :>230℃ (dec.)
Boiling point :490.8±45.0 °C(Predicted)
Density :1.283±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble2mg/mL, clear
pka :8.94±0.50(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :IBCXZJCWDGCXQT-UHFFFAOYSA-N
Boiling point :490.8±45.0 °C(Predicted)
Density :1.283±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble2mg/mL, clear
pka :8.94±0.50(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :IBCXZJCWDGCXQT-UHFFFAOYSA-N
Safety Information
| Symbol(GHS): |
 
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Description
Transforming growth factor-β (TGF-β) signals through a cell surface heteromeric complex involving type I (TGF-β RI) and type II (TGF-β RII) receptors. Downstream signal transduction is mediated by the TGF-β RI kinase domain through the phosphorylation of Smad proteins. LY364947 is a selective inhibitor of TGF-β RI (TGFR-I, TβR-I, ALK-5), with an IC50 value of 59 nM. LY364947 less effectively inhibits TGF-β RII (IC50 = 400 nM), p38 MAPK (IC50 = 740 nM), and mixed-lineage kinase 7 (MLK7; IC50 = 1,400 nM). It inhibits TGF-β-induced cell growth (IC50 = 89 nM) in NIH 3T3 mouse fibroblasts and TGF-β-directed Smad phosphorylation, synthesis of fibronectin, PAI-1 and uPA protein, and matrigel invasion in MDA-MB-231 cells.More related product prices
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