ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >TGF-beta / Smad >TGF-beta / Smad inhibitors >LY-364947
LY-364947
- CAS No.
- 396129-53-6
- Chemical Name:
- LY-364947
- Synonyms
- CS-576;Y364947;E 616451;LY-364947;HTS 466284;LY-364947, >=98%;LY 364947;LY-364947;LY-364947 USP/EP/BP;LY364947(HTS 466284);LY-364947, 396129-53-6
- CBNumber:
- CB3972214
- Molecular Formula:
- C17H12N4
- Molecular Weight:
- 272.3
- MOL File:
- 396129-53-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | >230℃ (dec.) |
|---|---|
| Boiling point | 490.8±45.0 °C(Predicted) |
| Density | 1.283±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble2mg/mL, clear |
| pka | 8.94±0.50(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| InChIKey | IBCXZJCWDGCXQT-UHFFFAOYSA-N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335-H400 | |||||||||
| Precautionary statements | P261-P273-P301+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T,N | |||||||||
| Risk Statements | 25-36/37/38-50/53 | |||||||||
| Safety Statements | 26-45-60-61 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933491090 | |||||||||
| NFPA 704 |
|
LY-364947 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | L6293 | LY-364947 ≥98% (HPLC) | 396129-53-6 | 5MG | ₹18694.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 616451-M | TGF-β RI Kinase Inhibitor - CAS 396129-53-6 - Calbiochem The TGF-β RI Kinase Inhibitor, also referenced under CAS 396129-53-6, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibit | 396129-53-6 | 616451-5MG | ₹19050 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L6293 | LY-364947 ≥98% (HPLC) | 396129-53-6 | 25MG | ₹74735.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 616451-M | TGF-β RI Kinase Inhibitor - CAS 396129-53-6 - Calbiochem The TGF-β RI Kinase Inhibitor, also referenced under CAS 396129-53-6, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibit | 396129-53-6 | 616451-100MG | ₹194953.92 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 616451-M | TGF-β RI Kinase Inhibitor - CAS 396129-53-6 - Calbiochem The TGF-β RI Kinase Inhibitor, also referenced under CAS 396129-53-6, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibit | 396129-53-6 | 616451-5UNMG | ₹1611522.08 | 2022-06-14 | Buy |
LY-364947 Chemical Properties,Uses,Production
Biological Activity
Selective inhibitor of TGF- β type-I receptor (TGF- β RI, TGFR-I, T β R-I, ALK-5) (IC 50 values are 59, 400 and 1400 nM for TGR- β RI, TGF- β RII and MLK-7K respectively). Inhibits TGF- β -dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC 50 values are 47 and 89 nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.
Biochem/physiol Actions
LY-364947 is a selective, ATP-competitive inhibitor of Transforming Growth Factor-β Type I receptor kinase (TGF-β RI, ALK5) with IC50 = 59 nM. It is much less potent at related kinases, with IC50 = 400 nM for TGF-β RII and IC50 = 1400 nM for mixed lineage kinase-7 (MLK-7), a kinase in the MAP kinase signal pathway and closely related to TGF-β RII. LY-364947 inhibits TGF-β-dependent cellular growth (IC50 = 81 nM) in NIH 3T3 mouse fibroblasts.
LY-364947 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 146)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | China | 5738 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 25247 | 58 | Inquiry |
| Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | China | 300 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | China | 9991 | 58 | Inquiry |
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LY 364947 4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]quinoline
LY-364947, 396129-53-6
Transforming Growth Factor-β Type I Receptor Kinase Inhibitor
LY-364947
LY-364947, >=98%
LY364947;HTS466284; LY-364947
TGF-β RI Kinase Inhibitor
[3-(Pyridin-2-yl)-4-(4-quinonyl)]-1H-pyrazole
4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline
LY364947(HTS 466284)
E 616451
HTS 466284
2-[4-(Quinolin-4-yl)-1H-pyrazol-3-yl]pyridine, 3-(Pyridin-2-yl)-4-(quinolin-4-yl)-1H-pyrazole
Quinoline, 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-
4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]quinoline E 616451
CS-576
LY 364947;LY-364947
LY-364947?,HTS 466284, >98%
TGF-β RI Kinase Inhibitor - CAS 396129-53-6 - Calbiochem
4-[(3-Pyridin-2-yl)-1H-pyrazol-4-yl)]quinoline 95+%
LY 364947;LY364947;HTS466284
Y364947
LY-364947 USP/EP/BP
LY-364947 LY364947 TGF-β RI Kinase Inhibitor
396129-53-6
6129-53-6
C17H12N4
API
Inhibitors
Smad
TGF-beta