LY3214996

CAS No.: 1951483-29-6

Chemical Name:: LY3214996

Synonyms: CS-2495;LY3214996;Temuterkib;Temuterkib (LY3214996);LY-3214996 (LY3214996);LY-3214996,LY 3214996,inhibit,Extracellular signal regulated kinases,Temuterkib,Inhibitor,ERK;6,6-dimethyl-2-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one;4H-Thieno[2,3-c]pyrrol-4-one, 5,6-dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-

CBNumber:: CB53168760

Molecular Formula:: C22H27N7O2S

Molecular Weight:: 453.56

MOL File:: 1951483-29-6.mol

Modify Date:: 2024/7/2 8:55:11

Request For Quotation

LY3214996 Properties

Boiling point	711.5±70.0 °C(Predicted)
Density	1.43±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:23.5(Max Conc. mg/mL);51.81(Max Conc. mM) Ethanol:16.0(Max Conc. mg/mL);35.28(Max Conc. mM)
form	A crystalline solid
pka	6.58±0.10(Predicted)
color	White to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319-H335-H302+H312+H332-H315

Precautionary statements

P301+P312-P302+P352-P305+P351+P338

HS Code

2934999090

NFPA 704

	0
2		0

LY3214996 Chemical Properties,Uses,Production

Description

LY3214996 is an inhibitor of ERK1 and ERK2 (IC₅₀ = 5 nM for both). It inhibits cell proliferation of tumor cells in vitro, including those expressing B-RAF, N-Ras, or K-Ras mutations. LY3214996 inhibits tumor growth in B-RAF or N-Ras mutant melanoma, B-RAF or K-Ras mutant colorectal, lung, and pancreatic cancer mouse xenograft models, as well as patient-derived xenograft (PDX) mouse models.

LY3214996 Preparation Products And Raw materials

Raw materials

Preparation Products

LY3214996 Suppliers

Global( 73)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	China	7513	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
Nanjing Doge Biomedical Technology Co., Ltd	+86-25-58227606 +86-15305155328	China	4128	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
Chemtour Biotech Co., Ltd	+8617327281506	China	1460	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
ATK CHEMICAL COMPANY LIMITED	60
Jinan Carbotang Biotech Co.,Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Nanjing Doge Biomedical Technology Co., Ltd	58
TargetMol Chemicals Inc.	58
Chemtour Biotech Co., Ltd	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58

LY3214996 Spectrum

LY3214996(1951483-29-6)¹HNMR

1951483-29-6(LY3214996)Related Search:

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LY3214996 6,6-dimethyl-2-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one CS-2495 4H-Thieno[2,3-c]pyrrol-4-one, 5,6-dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]- Temuterkib Temuterkib (LY3214996) LY-3214996,LY 3214996,inhibit,Extracellular signal regulated kinases,Temuterkib,Inhibitor,ERK LY-3214996 (LY3214996) 1951483-29-6