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LY-2562175

LY-2562175 Structure
CAS No.
1103500-20-4
Chemical Name:
LY-2562175
Synonyms
CS-2847;LY-2562175;LY 2562175,NR1H4,Inhibitor,LY-2562175,Autophagy,LY2562175,inhibit,FXR;6-(4-((5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic acid;1H-Indole-3-carboxylic acid, 6-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]-1-piperidinyl]-1-methyl-
CBNumber:
CB83303953
Molecular Formula:
C28H27Cl2N3O4
Molecular Weight:
540.44
MOL File:
1103500-20-4.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:27
Request For Quotation

LY-2562175 Properties

Boiling point 740.1±60.0 °C(Predicted)
Density 1.48±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 20 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
form A crystalline solid
pka 3.43±0.10(Predicted)
color White to light yellow

LY-2562175 Chemical Properties,Uses,Production

Description

LY2562175 is a farnesoid X receptor (FXR) agonist (EC50 = 193 nM in a reporter assay). It is selective for FXR over the glucocorticoid, androgen, mineralocorticoid, and progesterone receptors in HEK293 cells overexpressing the human receptors (EC50s = >10 μM for all in a radioligand binding assay). LY2562175 increases the interaction between FXR and steroid receptor coactivator 1 (SRC-1) with an EC50 value of 121 nM in a cell-free assay. It reduces plasma triglyceride and total cholesterol levels in LDL receptor-null mice (ED50s = 3.4 and 2 mg/kg, respectively). LY2562175 also decreases plasma LDL and increases HDL levels in Zucker diabetic fatty (ZDF) rats when administered at doses of 3, 10, and 30 mg/kg for nine days.

Uses

LY2562175, is a potent and selective FXR agonist with an EC50 of 193 nM.

LY-2562175 Preparation Products And Raw materials

Raw materials

Preparation Products

LY-2562175 Suppliers

Global( 38)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
Nantong Hanfang Biotechnology Co. , Ltd. 18616537568 China 30968 58 Inquiry
InvivoChem 13549236410 China 6747 58 Inquiry
Guangzhou Younan Technology Co., Ltd 020-020-82000279 18988968278 China 4324 58 Inquiry
Zhengzhou convergence chemical co., LTD 0371-0371-55153829 18003835034 China 9357 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
InvivoChem 58
Aladdin Scientific 58
Nantong Hanfang Biotechnology Co. , Ltd. 58
InvivoChem 58
Guangzhou Younan Technology Co., Ltd 58
Zhengzhou convergence chemical co., LTD 58

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LY-2562175 CS-2847 1H-Indole-3-carboxylic acid, 6-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]-1-piperidinyl]-1-methyl- LY 2562175,NR1H4,Inhibitor,LY-2562175,Autophagy,LY2562175,inhibit,FXR 6-(4-((5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic acid 1103500-20-4 C28H27Cl2N3O4