LY-3177833

CAS No.: 1627696-51-8

Chemical Name:: LY-3177833

Synonyms: CS-2783;LY-3177833;LY 3177833;LY-3177833;LY3177833,CDK,Cyclin dependent kinase,Inhibitor,inhibit,LY 3177833;(R)-3-(5-fluoropyrimidin-4-yl)-3-methyl-6-(1H-pyrazol-4-yl)isoindolin-1-one;1H-Isoindol-1-one, 3-(5-fluoro-4-pyrimidinyl)-2,3-dihydro-3-methyl-6-(1H-pyrazol-4-yl)-, (3R)-

CBNumber:: CB93139438

Molecular Formula:: C16H12FN5O

Molecular Weight:: 309.3

MOL File:: 1627696-51-8.mol

Modify Date:: 2024/7/2 8:55:41

Request For Quotation

LY-3177833 Properties

Boiling point	660.7±55.0 °C(Predicted)
Density	1.398±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:30.0(Max Conc. mg/mL);96.99(Max Conc. mM)
form	A crystalline solid
pka	11.67±0.40(Predicted)
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07,GHS08

Signal word

Danger

Hazard statements

H302-H315-H318-H334-H317-H341-H361-H370-H335-H413

Precautionary statements

P201-P202-P260-P264-P270-P272-P273-P280-P284-P301+P312-P302+P352-P304+P341-P305+P351+P338-P310-P308+P313-P321-P330-P362+P364-P333+P313-P342+P311-P363-P405-P501

NFPA 704

	0
3		0

LY-3177833 Chemical Properties,Uses,Production

Description

LY3177833 is an orally bioavailable inhibitor of Cdc7 kinase (IC₅₀ = 3.3 nM for ADP production in an enzyme assay). It inhibits phosphorylation of MCM2-S53 in H1299 cells (IC₅₀ = 0.29 μM). LY3177833 reduces tumor growth in an SW620 human colorectal adenocarcinoma mouse xenograft model when administered at doses of 10, 20, and 30 mg/kg twice per day.

LY-3177833 Preparation Products And Raw materials

Raw materials

Preparation Products

LY-3177833 Suppliers

Global( 48)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29824	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
Amadis Chemical Company Limited	571-89925085	China	131980	58	Inquiry
Shanghai Zeye Biotechnology Co., Ltd.	021-61998551 13122364865	China	9772	58	Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd.	15800340161	CHINA	6846	58	Inquiry
Shanghai tingchong biology science and technology co., ltd	18964309092 18964309092	China	2635	58	Inquiry

Supplier	Advantage
career henan chemical co	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai Zeye Biotechnology Co., Ltd.	58
Shanghai Hao Zhun Biological Technology Co., Ltd.	58
Shanghai tingchong biology science and technology co., ltd	58

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LY-3177833 (R)-3-(5-fluoropyrimidin-4-yl)-3-methyl-6-(1H-pyrazol-4-yl)isoindolin-1-one LY 3177833;LY-3177833 CS-2783 1H-Isoindol-1-one, 3-(5-fluoro-4-pyrimidinyl)-2,3-dihydro-3-methyl-6-(1H-pyrazol-4-yl)-, (3R)- LY3177833,CDK,Cyclin dependent kinase,Inhibitor,inhibit,LY 3177833 1627696-51-8