ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Angiogenesis >HIF inhibitor >2-METHOXYESTRADIOL
2-METHOXYESTRADIOL
- CAS No.
- 362-07-2
- Chemical Name:
- 2-METHOXYESTRADIOL
- Synonyms
- 2-Methoxy 17β-Estradiol;2-ME2;Panzem;2-MeOE2;NSC 659853;Methoxy estradiol;7-Methoxyestradiol;2-METHOXYESTRADIOL;2-METHOXYOESTRADIOL;2-Methoxy-β-estradiol
- CBNumber:
- CB5268052
- Molecular Formula:
- C19H26O3
- Molecular Weight:
- 302.41
- MOL File:
- 362-07-2.mol
- Modify Date:
- 2024/3/27 16:59:26
| Melting point | 188-190°C |
|---|---|
| Boiling point | 464.4±45.0 °C(Predicted) |
| Density | 1.178±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO: 10 mg/mL |
| form | crystalline |
| pka | 10.29±0.60(Predicted) |
| color | light yellow |
| λmax | 286nm(EtOH)(lit.) |
| InChIKey | CQOQDQWUFQDJMK-SSTWWWIQSA-N |
| CAS DataBase Reference | 362-07-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331-H315-H319-H335-H350-H360-H372-H410 | |||||||||
| Precautionary statements | P273-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338 | |||||||||
| Hazard Codes | T,Xi,N | |||||||||
| Risk Statements | 23/24/25-36/37/38-48-61-60-46-45-51/53 | |||||||||
| Safety Statements | 22-26-36/37/39-45-53-36-61 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KG7537500 | |||||||||
| HS Code | 2937.23.5050 | |||||||||
| NFPA 704 |
|
2-METHOXYESTRADIOL price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M6383 | 2-Methoxyestradiol powder | 362-07-2 | 5MG | ₹9049.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M6383 | 2-Methoxyestradiol powder | 362-07-2 | 10MG | ₹12914.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M6383 | 2-Methoxyestradiol powder | 362-07-2 | 50MG | ₹41773.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 454180 | 2-Methoxyestradiol - CAS 362-07-2 - Calbiochem A natural metabolite of 17β-estradiol that is devoid of estrogenic activity. | 362-07-2 | 10MG | ₹9490 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 454180 | 2-Methoxyestradiol - CAS 362-07-2 - Calbiochem A natural metabolite of 17β-estradiol that is devoid of estrogenic activity. | 362-07-2 | 50MG | ₹32230 | 2022-06-14 | Buy |
2-METHOXYESTRADIOL Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity.
Definition
ChEBI: A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.
Biological Activity
Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.
2-METHOXYESTRADIOL Preparation Products And Raw materials
Global( 249)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| VIVAN Life Sciences Pvt. Limited. | +91(22) 2544 4584 / 2544 4585 | New Delhi, India | 138 | 50 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Hong Kong Excellence Biotechnology Co., Ltd. | +86-86-18838029171 +8618126314766 | China | 887 | 58 | Inquiry |
| Sigma Audley | +86-18336680971 +86-18126314766 | China | 497 | 58 | Inquiry |
| Hebei Kangcang new material Technology Co., LTD | +8615713292910 | China | 341 | 58 | Inquiry |
| Shanghai Aosiris new Material Technology Co., LTD | 86-15139564871 +8615139564871 | China | 264 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 16209 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21675 | 55 | Inquiry |
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2-METHOXYESTRADIOL \ INHIBITOR OF CELL P ROLIFERATION AND ANGIOGENESIS
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NSC 659853
Panzem
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(17)-2-Methoxy-estra-1,3,5(10)-triene-3,17-diol
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(17B)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIOL
2-Methoxy-beta-estradiol
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(17β)-2-Methoxyestradiol
17β-2-Methoxyestradiol
3,17β-Dihydroxy-2-methoxy-1,3,5(10)-estratriene
7-Methoxyestradiol
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2-Methoxy-[13C,2H3]-estradiol
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1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-METHYL ETHER
2-Methoxyestradiol (NSC-659853)
2-Methoxyestradiol - CAS 362-07-2 - Calbiochem
2-Methoxy-β-estradiol>
Methoxy estradiol
Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17β)-
2-METHOXYESTRADIOL USP/EP/BP
2-Methoxyestradiol (2MeOE2, NSC659853, 2ME2)
362-07-2 2-METHOXYESTRADIOL
2-Methoxy-β-estradiol
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(17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol
362-07-2
363-07-2
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