Estradiol
- CAS No.
- 57-91-0
- Chemical Name:
- Estradiol
- Synonyms
- α-Estradiol;BETA-ESTRADIOL;B-ESTRADIOL;ALPHA-ESTRADIOL;17B-ESTRADIOL;Alfatradiol;17α-estradiol;17A-ESTRADIOL;17ALPHA-ESTRADIOL;Estradiol EP Impurity B
- CBNumber:
- CB7289534
- Molecular Formula:
- C18H24O2
- Molecular Weight:
- 272.39
- MOL File:
- 57-91-0.mol
- Modify Date:
- 2024/5/8 14:48:35
| Melting point | 176-180 °C(lit.) |
|---|---|
| Boiling point | 355.44°C (rough estimate) |
| alpha | D20 +53 to +56° (c = 0.9 in dioxane) |
| Density | 1.0708 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | ethanol: 50 mg/mL, clear, colorless |
| form | powder |
| pka | 10.27±0.60(Predicted) |
| color | white with slight yellow |
| Water Solubility | 3.9mg/L(25 ºC) |
| Merck | 14,3704 |
| CAS DataBase Reference | 57-91-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0) |
| EPA Substance Registry System | Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H341-H351-H360F-H362-H410 |
| Precautionary statements | P201-P202-P260-P263-P273-P308+P313 |
| Hazard Codes | T,Xn |
| Risk Statements | 45-48-40 |
| Safety Statements | 53-45-24/25-22 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | KG3750000 |
| F | 8-10 |
| HS Code | 29372390 |
Estradiol price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | E8750 | α-Estradiol powder, ≥98% (TLC) | 57-91-0 | 100MG | ₹10576.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E8750 | α-Estradiol powder, ≥98% (TLC) | 57-91-0 | 500MG | ₹41568 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E8750 | α-Estradiol powder, ≥98% (TLC) | 57-91-0 | 1G | ₹74898.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 46542 | α-Estradiol VETRANAL?, analytical standard | 57-91-0 | 100MG | ₹12784.33 | 2022-06-14 | Buy |
| TCI Chemicals (India) | E0919 | α-Estradiol min. 98.0 % | 57-91-0 | 1G | ₹20800 | 2022-05-26 | Buy |
Estradiol Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.
Definition
ChEBI: An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer).
Biological Activity
Endogenous estrogen receptor ligand (K i values are 0.2 and 1.2 nM for ER α and ER β receptors respectively).
Purification Methods
17-Estradiol recrystallises from aqueous EtOH (80%) as the hemihydrate and differs from the -anomer (below) by not precipitating with digitonin in 80% aqueous EtOH. The diacetate [1474-52-8] crystallises from aqueous EtOH in needles with m 139-140o. The 3-benzoate crystallises in three forms m 158o, 153o and 63o.
Estradiol Preparation Products And Raw materials
Global( 340)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Anant Pharmaceuticals Pvt. ltd | +91 8550986868 | Maharashtra, India | 736 | 58 | Inquiry |
| Olympus Chemicals & Fertilizers | 08068441058Ext 121 | Maharashtra, India | 486 | 58 | Inquiry |
57-91-0(Estradiol)Related Search:
BETA-ESTRADIOL 3-BENZOATE,BETA-ESTRADIOL BENZOATE,B-ESTRADIOL-3-BENZOATE
BETA-ESTRADIOL 17-VALERATE
EPIMESTROL
Inositol
Estradiol Cypionate
Acid Red 94
Quinestrol
β-Estradiol
Ethynyl estradiol
ESTRADIOL 17-HEPTANOATE,BETA-ESTRADIOL-17-ENANTHATE
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1of4
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1,3,5-estratriene-3,17-alpha-diol
1,3,5-Estratriene-3,17alpha-diol
17alpha-Oestradiol
3,17alpha-Dihydroxyestra-1,3,5(10)-triene
3,17-alpha-dihydroxyoestra-1,3,5(10)-triene
3,17alpha-Dihydroxyoestra-1,3,5(10)-triene
5(10)-triene-3,17-diol,(17-alpha)-estra-3
epiestradial
Estra-1,3,5(10)-triene-3,17alpha-diol
Estra-1,3,5(10)-triene-3,17-diol, (17alpha)-
Estradiol, 17alpha-
Oestra-1,3,5(10)-triene-3,17alpha-diol
Oestradiol-17alpha
oestradiol-17-alpha
1,3,5(10)-estratriene-3,17α-diol
A-ESTRADIOL
(8S,9S,13S,14S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta
17A-ESTRADIOL-CARC USP28
1,3,5-Estratriene-3,17β-diol, 3,17β-Dihydroxy-1,3,5(10)-estratriene
C02537
α-Estradiol,1,3,5(10)-Estratriene-3,17α-diol, 3,17α-Dihydroxy-1,3,5(10)-estratriene, Epiestradiol
13β-Methyl-1,3,5(10)-gonatriene-3,17α-diol
17-Epiestradiol
17α-Oestradiol
3,17α-Dihydroxyoestra-1,3,5(10)-triene
Epiestrol
IMp. L (EP): Estra-1,3,5(10)-triene-3,17a-diol (17a-Estradiol
ESTRADIOL, 17a-(P)
17-epi-Estradiol (Estradiol IMpurity B)
Epiestradiol
17a-Estradiol
17a-Estradiol solution,100ppm
CIS-ESTRADIOL
EPIESTRADIOL
E 2
DIOGYN
ESTROVITE
estra-1,3,5(10)-triene-3,17a-diol
ESTRA-1,3,5(10)-TRIENE-3,17BETA-DIOL
ESTRADIOL, 17A-
ESTRADIOL, 17B-
17BETA-OESTRADIOL
1,3,5(10)-ESTRATRIEN-3,17-DIOL
1,3,5[10]-ESTRATRIENE-3,17ALPHA-DIOL
1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL
1,3,5(10)-ESTRATRIEN-3,17-ALPHA-DIOL
1,3,5(10)-ESTRATRIEN-2,17BETA-DIOL
1,3,5(10)-ESTRADRIEN-3,17A-DIOL
17A-ESTRADIOL-CARC.
OESTRADIOL (E2), 17-ALPHA-
OESTRADIOL (E2), 17-BETA-
(8R,9S,13S,14S,17S)-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL
3,17-DIHYDROXYESTRATRIENE
3,17ALPHA-DIHYDROXY-1,3,5[10]-ESTRATRIENE
Ethinylestradiol Impurity 12（Ethinylestradiol EP Impurity L）
Estradiol Impurity 2(Estradiol EP Impurity B)
3-O-Methyl-6-oxo 17&beta
4-Methyl-17&alpha
2-Methoxy-d3 17&beta