Estradiol Cypionate
- CAS No.
- 313-06-4
- Chemical Name:
- Estradiol Cypionate
- Synonyms
- ESTRADIOL CYPIONATE;Estrofem;Estradiol cyclopentylpropionate;3-cyclopentylpropanoic acid [(13S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] ester;Depogen;Estrapo;Estradep;Dep-Estro;Depoestra;DEPOFEMIN
- CBNumber:
- CB9410729
- Molecular Formula:
- C26H36O3
- Molecular Weight:
- 396.57
- MOL File:
- 313-06-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/11/16 15:32:52
| Melting point | 151-152° |
|---|---|
| alpha | D25 +45° (chloroform) |
| Boiling point | 460.24°C (rough estimate) |
| Density | 1.0828 (rough estimate) |
| refractive index | 1.4700 (estimate) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 10.25±0.60(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChIKey | UOACKFBJUYNSLK-JCRQLOERNA-N |
| SMILES | C[C@]12CC[C@]3([H])C4C=CC(O)=CC=4CC[C@@]3([H])[C@]1([H])CC[C@@H]2OC(=O)CCC1CCCC1 |&1:1,4,15,17,21,r| |
| CAS DataBase Reference | 313-06-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Estradiol cypionate(313-06-4) |
| EPA Substance Registry System | Estra-1,3,5(10)-triene-3,17-diol (17.beta.)-, 17-cyclopentanepropanoate (313-06-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302+H312+H332-H350-H360 |
| Precautionary statements | P201-P280-P301+P312-P302+P352+P312-P304+P340+P312-P308+P313 |
| Hazard Codes | T,Xi |
| Risk Statements | 45-46-61-20/21/22-36/37/38 |
| Safety Statements | 53-22-36/37/39-45-26 |
| WGK Germany | 3 |
| RTECS | KG4600000 |
| HS Code | 29372390 |
Estradiol Cypionate price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR2839 | Estradiol Cypionate certified reference material, pharmaceutical secondary standard | 313-06-4 | 500MG | ₹23717.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E8004 | β-Estradiol 17-cypionate | 313-06-4 | 1G | ₹17222.58 | 2022-06-14 | Buy |
Estradiol Cypionate Chemical Properties,Uses,Production
Chemical Properties
Estradiol cypionate is a White to Off-White Solid. It is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). The solubility of estradiol cypionate in ethanol is approximately 20 mg/ml and approximately 15 mg/ml in DMSO and DMF.
Uses
Estradiol Cypionate is the cypionate salt form of estradiol, the most potent, naturally produced estrogen. Estradiol Cypionate is present in injectable contraceptive formulations. Used in hormone replacement therapy with potential for improving cognition in post-menopausal women.
Definition
ChEBI: Estradiol 17beta-cyclopentylpropionate is a steroid ester. It inhibits ET-1 synthesis via estrogen receptor.
Pharmacokinetics
Estradiol cypionate/medroxyprogesterone acetate is a combined injectable contraceptive containing 5 mg estradiol cypionate and 25 mg medroxyprogesterone acetate in microcrystalline aqueous suspension for once-monthly intramuscular administration. With this formulations, estradiol levels peak 2 to 3 days post-injection with average maximal circulating levels of about 250 pg/mL. The elimination half-life of estradiol with these formulations is 8.4 to 10.1 days, and circulating estradiol levels return to a baseline of about 50 pg/mL approximately 14 to 24 days post-injection
Side effects
The side effects of estradiol cypionate are the same as those of estradiol. The side effects of Estradiol Cypionate include breast tenderness and enlargement, nausea, vomiting, bloating, edema, headache, migraine, and melasma. High-dose estrogen therapy with estradiol cypionate injections may also cause an increased risk of thromboembolism, changes in blood lipid profile, increased insulin resistance, and increased levels of prolactin.
Safety Profile
An experimental teratogen. Other experimental reproductive effects. A steroid. When heated to decomposition it emits acrid smoke and fumes.
Mode of action
Estradiol cypionate diffuses through the cell membrane and binds to and subsequently activates the nuclear estrogen receptor found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated complex binds to the estrogen response element on the DNA and activates the transcription of genes involved in the functioning of the female reproductive system and secondary sex characteristics.
Estradiol Cypionate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Shakti Life Science | +91-9930420063 +91-9930420063 | Maharashtra, India | 28 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| Swati Spentose Pvt. Ltd. | +91 22 66332427 | New Delhi, India | 17 | 58 | Inquiry |
| Ajila Chandrahas Enterprise | 08048250329Ext 854 | Karnataka, India | 4 | 58 | Inquiry |
| Ralington Pharma. | 91-79-48911722 | Gujarat, India | 311 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6754 | 58 | Inquiry |
| Hebei Bonster Technology Co.,Limited | +8613315996897 | China | 792 | 58 | Inquiry |
313-06-4(Estradiol Cypionate)Related Search:
1of4
chevron_right