LY-2562175
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- ₹0
- Product name: LY-2562175
- CAS: 1103500-20-4
- MF: C28H27Cl2N3O4
- MW: 540.44
- EINECS:-0
- MDL Number:MFCD30738721
- Synonyms:LY-2562175;CS-2847;1H-Indole-3-carboxylic acid, 6-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]-1-piperidinyl]-1-methyl-;LY 2562175,NR1H4,Inhibitor,LY-2562175,Autophagy,LY2562175,inhibit,FXR;6-(4-((5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic acid
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Properties
Boiling point :740.1±60.0 °C(Predicted)
Density :1.48±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 20 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
form :A crystalline solid
pka :3.43±0.10(Predicted)
color :White to light yellow
Density :1.48±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 20 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
form :A crystalline solid
pka :3.43±0.10(Predicted)
color :White to light yellow
Safety Information
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Description
LY2562175 is a farnesoid X receptor (FXR) agonist (EC50 = 193 nM in a reporter assay). It is selective for FXR over the glucocorticoid, androgen, mineralocorticoid, and progesterone receptors in HEK293 cells overexpressing the human receptors (EC50s = >10 μM for all in a radioligand binding assay). LY2562175 increases the interaction between FXR and steroid receptor coactivator 1 (SRC-1) with an EC50 value of 121 nM in a cell-free assay. It reduces plasma triglyceride and total cholesterol levels in LDL receptor-null mice (ED50s = 3.4 and 2 mg/kg, respectively). LY2562175 also decreases plasma LDL and increases HDL levels in Zucker diabetic fatty (ZDF) rats when administered at doses of 3, 10, and 30 mg/kg for nine days.Related product price
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