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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Protein tyrosine kinase /JAK / STAT >JAK inhibitors >LY 2784544

LY 2784544

LY 2784544 Structure
  • ₹13466.3 - ₹54222.43
  • Product name: LY 2784544
  • CAS: 1229236-86-5
  • MF: C23H25ClFN7O
  • MW: 469.94
  • EINECS:-0
  • MDL Number:MFCD20482143
  • Synonyms:LY2784544(gandotinib);3-(4-Chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[;3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine;LY 2784544;3-[(4-Chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine;3-(4-chloro-2-fluorobenzyl)-2-Methyl-N-(3-Methyl-1H-pyrazol-5-yl)-8-(MorpholinoMethyl)iMidazo[1,2-b]pyridazin-6-aMine;LY2784544/LY-2784544;IMidazo[1,2-b]pyridazin-6-aMine, 3-[(4-chloro-2-fluorophenyl)Methyl]-2-Methyl-N-(5-Methyl-1H-pyrazol-3-yl)-8-(4-MorpholinylMethyl)-
Price2 Properties Safety Information Description
2 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML2567
  • Product descriptionLY2784544 ≥98% (HPLC)
  • Packaging5MG
  • Price₹13466.3
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML2567
  • Product descriptionLY2784544 ≥98% (HPLC)
  • Packaging25MG
  • Price₹54222.43
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML2567 LY2784544 ≥98% (HPLC) 5MG ₹13466.3 2022-06-14 Buy
Sigma-Aldrich(India) SML2567 LY2784544 ≥98% (HPLC) 25MG ₹54222.43 2022-06-14 Buy

Properties

Density :1.45
storage temp. :Store at -20°C
solubility :≥23.5 mg/mL in DMSO; insoluble in H2O; ≥5.65 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :14.12±0.10(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

LY2784544 is a potent, ATP-competitive inhibitor of janus kinase 2 (JAK2) that less effectively inhibits JAK3 (IC50s = 3 and 48 nM, respectively). It also inhibits JAK2 containing the V617F mutation (IC50 = 20 nM), blocking STAT5 phosphorylation and proliferation of Ba/F3 pro-B-cells expressing this constitutively active JAK2 mutant form. When given by oral gavage, LY2784544 significantly reduces the growth of Ba/F3 pro-B-cells in SCID mice without affecting erythroid progenitors, reticulocytes, or platelets. JAK inhibitors, including LY2784544, may be useful in hematological malignancies.

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Suppliers and manufacturers

Apeloa production Co.,Limited
LY2784544
₹1.00 /1g
LY2784544 CAS:1229236-86-5
career henan chemical co
LY 2784544
₹2.00 /1kg
LY 2784544 CAS:1229236-86-5
A.J Chemicals SynZeal Research Pvt Ltd
Shandong Risen-Sun Pharmaceutical Co., Ltd
Capot Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED