(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
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- ₹21390.2 - ₹75894.08
- Product name: (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
- CAS: 1268524-70-4
- MF: C23H25ClN4O2S
- MW: 456.99
- EINECS:
- MDL Number:MFCD22683748
- Synonyms:(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thienol[3,2-f][1,2,4]troazolo[4,3-a][1,4]diazepin-6-yl)acetate[(+)-6];(+)-JQ1,(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(+)-JQ1,(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate CAS:;BroModoMain Inhibitor, (+)-JQ1;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-triMethyl-, 1,1-diMethylethyl ester, (6S)-;(S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate (+)-JQ-1;(6s)-6-(2-Tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-F][1,2,4]triazolo[4,3-A][1,4]diazepin-10-ium
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1524
- Product description(+)-JQ1 ≥98% (HPLC)
- Packaging5MG
- Price₹21390.2
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1524
- Product description(+)-JQ1 ≥98% (HPLC)
- Packaging25MG
- Price₹75894.08
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML1524 | (+)-JQ1 ≥98% (HPLC) | 5MG | ₹21390.2 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML1524 | (+)-JQ1 ≥98% (HPLC) | 25MG | ₹75894.08 | 2022-06-14 | Buy |
Properties
Melting point :>205°C (dec.)
Boiling point :610.4±65.0 °C(Predicted)
Density :1.33
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :2.05±0.60(Predicted)
color :white to beige
Stability :Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChIKey :DNVXATUJJDPFDM-KRWDZBQOSA-N
Boiling point :610.4±65.0 °C(Predicted)
Density :1.33
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :2.05±0.60(Predicted)
color :white to beige
Stability :Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChIKey :DNVXATUJJDPFDM-KRWDZBQOSA-N
Safety Information
Symbol(GHS): |
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Description
The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. JQ1 displaces BET proteins from chromatin by competitively binding to the acetyl-lysine recognition pocket of BET bromodomains. Enantiomerically pure (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively, whereas the (?)-JQ1 stereoisomer has no appreciable affinity to BET bromodomains. JQ1 has been used as a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis. See the Structural Genomics Consortium (SGC) website for more information.Related product price
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