Enasidenib
- ₹0
- Product name: Enasidenib
- CAS: 1446502-11-9
- MF: C19H17F6N7O
- MW: 473.38
- EINECS:
- MDL Number:MFCD29472245
- Synonyms:Enasidenib(AG-221);AG-221 (Enasidenib);AG-211;2-Methyl-1-(4-(6-(trifluoromethyl)pyridin-2-yl)-6-(2-(trifluoromethyl)pyridin-4-ylamino)-1,3,5-triazin-2-ylamino)propan-2-ol;Enasidenib;AG-221;2-Propanol, 2-methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-;Enasidenib Mesylate
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Properties
Melting point :168-170°C
Boiling point :581.0±60.0 °C(Predicted)
Density :1.477±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 25 mg/ml)
form :solid
pka :14.70±0.29(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Boiling point :581.0±60.0 °C(Predicted)
Density :1.477±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 25 mg/ml)
form :solid
pka :14.70±0.29(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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Description
Enasidenib (1446502-11-9) is a potent (IC50’s = 100 nM IDH2R140Q homodimer, 30 nM IDH2R140Q/WT heterodimer and 10 nM IDH2R172K/WT heterodimer) and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2).1? It suppressed the production of the oncometabolite (R)-2-Hydroxyglutarate (a competitive inhibitor of αKG-dependent dioxygenases which leads to epigenetic dysregulation) and induced cellular differentiation in primary human IDH2 mutation-positive acute myeloid leukemia cells.1,2? Recently approved for clinical use by the FDA.More related product prices
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Suppliers and manufacturers
CLEARSYNTH LABS LTD.
SynZeal Research Pvt Ltd
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
TargetMol Chemicals Inc.
ANHUI WITOP BIOTECH CO., LTD
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem