AZD6738
- ₹0
- Product name: AZD6738
- CAS: 1352226-88-0
- MF: C20H24N6O2S
- MW: 412.51
- EINECS:805-672-6
- MDL Number:MFCD28952790
- Synonyms:AZD6738;4-[4-[1-[[S(R)]-S-Methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine;AZD6738(AZD-6738);(R)-imino(methyl)(1-(6-((R)-3-methylmorpholino)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)cyclopropyl)-l6-sulfanone;EOS-61602;(R)-3-methyl-4-(6-(1-((R)-S-methylsulfonimidoyl)cyclopropyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)morpholine;1H-Pyrrolo[2,3-b]pyridine, 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-;AZD-6738;AZD 6738;AZD6738
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|
Properties
Density :1.52±0.1 g/cm3(Predicted)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :12.53±0.40(Predicted)
color :Pale Yellow
InChIKey :OHUHVTCQTUDPIJ-YEMGFFRQNA-N
SMILES :C12NC=CC1=C(C1=NC(N3CCOC[C@H]3C)=CC(C3([S@](C)(=N)=O)CC3)=N1)C=CN=2 |&1:14,19,r|
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :12.53±0.40(Predicted)
color :Pale Yellow
InChIKey :OHUHVTCQTUDPIJ-YEMGFFRQNA-N
SMILES :C12NC=CC1=C(C1=NC(N3CCOC[C@H]3C)=CC(C3([S@](C)(=N)=O)CC3)=N1)C=CN=2 |&1:14,19,r|
Safety Information
Symbol(GHS): | ||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Warning | |||||||||||||||||||||||||||||||||||
Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
Precautionary statements: |
|
Description
AZD 6738 is an orally bioavailable inhibitor of the serine/threonine protein kinase ataxia telangiectasia mutated (ATM) and Rad3-related (ATR; IC50 = 1 nM). It can inhibit ATR substrate Chk1 Ser345 phosphorylation in cells with an IC50 value of 74 nM. AZD 6738 has been shown to inhibit the proliferation of various solid and hematological cell lines with IC50 values of less than 1 μM and to reduce tumor growth in several ATM-deficient xenograft models. When used in combination with either DNA damaging chemotherapy agents or ionizing radiation, AZD 6738 demonstrated synergistic cell killing activity across multiple cell lines in vitro and in xenograft studies.More related product prices
1204669-58-8 RVX-208 Enasidenib 1218942-37-0 BLU 9931 DBeQ 312756-74-4 LLY-507 914471-09-3 199666-03-0 MS023 SGC707Related product price
- DBeQ
₹7500-46509 - 312756-74-4
₹8210-45410.88 - 199666-03-0
₹13044.13-52620.33
Suppliers and manufacturers
A.J Chemicals
Wuhan Jingkang en Biomedical Technology Co., Ltd
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Chongqing Chemdad Co., Ltd
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
Wuhan Nutra Biotechnology Co.,Ltd
Zhejiang J&C Biological Technology Co.,Limited
CR Corporation Limited