Selonsertib
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- Product name: Selonsertib
- CAS: 1448428-04-3
- MF: C24H24FN7O
- MW: 445.49
- EINECS:
- MDL Number:MFCD29920355
- Synonyms:Selonsertib;5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]benzamide;Selonsertib GS-4997;GS-4497;GS-4997;ASK-1;GS4997 SELONSERTIB;5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-methylbenzamide;Benzamide, 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-
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Properties
Melting point :>180°C (dec.)
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
pka :11.21±0.70(Predicted)
form :solid
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference :1448428-04-3
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
pka :11.21±0.70(Predicted)
form :solid
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference :1448428-04-3
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Selonsertib (1448428-04-3) is a potent Apoptosis signal-regulating kinase 1 (ASK1) inhibitor (pIC50 = 8.3)1 found to improve metabolic parameters in nonalcoholic steatohepatitis, reduce hepatic steatosis, inflammation, and fibrosis2-4. Selonsertib suppressed the efflux function of multidrug resistance (MDR) transporters ABCB1 and ABCG2.5Related product price
- 1268524-70-4
₹21390.2-75894.08 - 101574-65-6
₹10954.9-43126.8 - 1014691-61-2
₹14440
