SH-4-54
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- ₹0
- Product name: SH-4-54
- CAS: 1456632-40-8
- MF: C29H27F5N2O5S
- MW: 610.59
- EINECS:
- MDL Number:MFCD28143917
- Synonyms:4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-Benzoic Acid SH-4-54;SH-4-54;4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-benzoic acid;Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-;CS-1773;SH-4-54 USP/EP/BP;SH 4 54,Inhibitor,SH454,inhibit,STAT
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Properties
Boiling point :717.2±70.0 °C(Predicted)
Density :1.431±0.06 g/cm3(Predicted)
storage temp. :Desiccate at -20°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml
form :A crystalline solid
pka :4.29±0.10(Predicted)
color :White to off-white
Density :1.431±0.06 g/cm3(Predicted)
storage temp. :Desiccate at -20°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml
form :A crystalline solid
pka :4.29±0.10(Predicted)
color :White to off-white
Safety Information
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Description
SH-4-54 is an inhibitor of signal transducer and activator of transcription 3 (STAT3; IC50 = 4.7 μM for STAT3 homodimer DNA binding activity). It selectively inhibits STAT3 homodimer over STAT1 and STAT5 homodimer and STAT3:STAT1 heterodimer DNA binding in EGF-stimulated NIH3T3/hEGFR nuclear extracts containing activated STAT1, STAT3, and STAT5 and decreases STAT3 iNOS, Survivin, and Bcl-2 promoter occupancy in MDA-MB-231 cells. SH-4-54 inhibits growth of glioma, breast, and prostate cancer cell lines that express constitutively active STAT3 (IC50s = 1-7.4, 3.8-4.5, and 5.3-5.8 μM, respectively). In vivo, SH-4-54 (3 mg/kg per day) inhibits tumor growth in the U251MG glioma and MDA-MB-231 breast cancer mouse xenograft models.Related product price
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