SHA 68
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- Product name: SHA 68
- CAS: 847553-89-3
- MF: C26H24FN3O3
- MW: 445.49
- EINECS:
- MDL Number:MFCD22683843
- Synonyms:SHA 68;N-(4-fluorobenzyl)-3-oxo-1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxamide;N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide;3H-Oxazolo[3,4-a]pyrazine-7(1H)-carboxamide, N-[(4-fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-
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Properties
Boiling point :727.8±60.0 °C(Predicted)
Density :1.35±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 16 mg/ml; DMSO: 14 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml
form :A crystalline solid
pka :13.32±0.40(Predicted)
color :White to off-white
Density :1.35±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 16 mg/ml; DMSO: 14 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml
form :A crystalline solid
pka :13.32±0.40(Predicted)
color :White to off-white
Safety Information
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Description
SHA-68 is an antagonist of the neuropeptide S receptor (NPSR; IC50s = 22 and 23.8 nM for the NPSR Asn107 and NPSR Ile107 isoforms, respectively). It is selective for NPSR over a panel of 14 G protein-coupled receptors exhibiting no activity at a concentration of 10 μM. SHA-68 (50 mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing in mice. SHA-68 also reduces conditioned reinstatement of cocaine seeking in rats.More related product prices
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