AZD 1480
- ₹13875 - ₹55810.8
- Product name: AZD 1480
- CAS: 935666-88-9
- MF: C14H14ClFN8
- MW: 348.77
- EINECS:
- MDL Number:MFCD16038904
- Synonyms:5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine;AZD 1480;(S)-5-chloro-N4-(5-Methyl-1H-pyrazol-3-yl)-N2-(1-(5-MethylpyriMidin-2-yl)ethyl)pyriMidine-2,4-diaMine;(S)-5-chloro-N2-(1-(5-fluoropyriMidin-2-yl)ethyl)-N4-(5-Methyl-1H-pyrazol-3-yl)pyriMidine-2,4-diaMine;5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine AZD 1480;AZD 1480 5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine;AZD1480, >=98%;AZD1480;AZD1480;AZD 1480
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1505
- Product descriptionAZD1480 ≥98% (HPLC)
- Packaging5MG
- Price₹13875
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1505
- Product descriptionAZD1480 ≥98% (HPLC)
- Packaging25MG
- Price₹55810.8
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML1505 | AZD1480 ≥98% (HPLC) | 5MG | ₹13875 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML1505 | AZD1480 ≥98% (HPLC) | 25MG | ₹55810.8 | 2022-06-14 | Buy |
Properties
Melting point :>205°C (dec.)
Boiling point :575.2±60.0 °C(Predicted)
Density :1.517
storage temp. :-20°C
solubility :Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly, Heat
form :powder
pka :13.73±0.10(Predicted)
color :white to beige
InChI :InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1
InChIKey :PDOQBOJDRPLBQU-QMMMGPOBSA-N
SMILES :C1(N[C@H](C2=NC=C(F)C=N2)C)=NC=C(Cl)C(NC2C=C(C)NN=2)=N1
Boiling point :575.2±60.0 °C(Predicted)
Density :1.517
storage temp. :-20°C
solubility :Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly, Heat
form :powder
pka :13.73±0.10(Predicted)
color :white to beige
InChI :InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1
InChIKey :PDOQBOJDRPLBQU-QMMMGPOBSA-N
SMILES :C1(N[C@H](C2=NC=C(F)C=N2)C)=NC=C(Cl)C(NC2C=C(C)NN=2)=N1
Safety Information
Symbol(GHS): | |||||||||||||||
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Signal word: | Warning | ||||||||||||||
Hazard statements: |
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Precautionary statements: |
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Description
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F). AZD1480 is a potent JAK2 inhibitor that blocks signaling (IC50 = 58 nM at 5 mM ATP) and proliferation of JAK2-expressing cell lines (GI50 = 60 nM). It is selective for JAK2 over other JAK family members as well as a panel of related kinases. AZD1480 also inhibits the growth of cells expressing the V617F mutant of JAK2 (GI50 = 60 nM). It reversibly blocks JAK2-mediated phosphorylation of STAT3 and STAT5. AZD1480 displays good pharmacokinetics in vivo, inhibits STAT3 and STAT5 activation in vivo, and suppresses tumorigenesis in mouse xenografts harboring constitutive STAT3 activity. In addition to suppressing myeloma cell growth and survival, AZD1480 reduces angiogenesis and metastasis in vitro and in human xenograft tumor models.More related product prices
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₹1.00 /1KG
5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine CAS:935666-88-9
5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine CAS:935666-88-9