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ChemicalBook >> CAS DataBase List >> (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate price.
  • $28 - $5000
  • Product name: (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
  • CAS: 1268524-70-4
  • MF: C23H25ClN4O2S
  • MW: 456.99
  • EINECS:
  • MDL Number:MFCD22683748
  • Synonyms:(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thienol[3,2-f][1,2,4]troazolo[4,3-a][1,4]diazepin-6-yl)acetate[(+)-6];(+)-JQ1,(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(+)-JQ1,(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate CAS：;BroModoMain Inhibitor, (+)-JQ1;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-triMethyl-, 1,1-diMethylethyl ester, (6S)-;(S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate (+)-JQ-1;(6s)-6-(2-Tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-F][1,2,4]triazolo[4,3-A][1,4]diazepin-10-ium
Price44 Properties Safety Information Description
44 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • BroadPharm
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
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  • 1g
  • 5g
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-3004-M010
  • Product description(+)-JQ1 ≥95%
  • Packaging10mg
  • Price$394
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX6914
  • Product description(+)-JQ-1
  • Packaging1g
  • Price$1342
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA529842
  • Product description(S)-tert-Butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98+%
  • Packaging1g
  • Price$933
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA529842
  • Product description(S)-tert-Butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98+%
  • Packaging250mg
  • Price$370
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA529842
  • Product description(S)-tert-Butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98+%
  • Packaging100mg
  • Price$206
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA529842
  • Product description(S)-tert-Butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98+%
  • Packaging50mg
  • Price$122
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA529842
  • Product description(S)-tert-Butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98+%
  • Packaging25mg
  • Price$88
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA529842
  • Product description(S)-tert-Butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98+%
  • Packaging10mg
  • Price$62
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA529842
  • Product description(S)-tert-Butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98+%
  • Packaging5mg
  • Price$48
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1910
  • Product descriptionBromodomainInhibitor,(+)-JQ1
  • Packaging50mg
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60008
  • Product description(+)-JQ1
  • Packaging20mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146221
  • Product description(+)-JQ1 HPLC > 99%,ee > 99%
  • Packaging100mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146221
  • Product description(+)-JQ1 HPLC > 99%,ee > 99%
  • Packaging250mg
  • Price$1060.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146221
  • Product description(+)-JQ1 HPLC > 99%,ee > 99%
  • Packaging1g
  • Price$2395.3
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC43273
  • Product description(+)-JQ 1
  • Packaging10mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC43273
  • Product description(+)-JQ 1
  • Packaging50mg
  • Price$437.5
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-3004-M010 (+)-JQ1 ≥95% 10mg $394 2021-12-16 Buy
AK Scientific X6914 (+)-JQ-1 1g $1342 2021-12-16 Buy
Ambeed A529842 (S)-tert-Butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98+% 1g $933 2021-12-16 Buy
Ambeed A529842 (S)-tert-Butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98+% 250mg $370 2021-12-16 Buy
Ambeed A529842 (S)-tert-Butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98+% 100mg $206 2021-12-16 Buy
Ambeed A529842 (S)-tert-Butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98+% 50mg $122 2021-12-16 Buy
Ambeed A529842 (S)-tert-Butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98+% 25mg $88 2021-12-16 Buy
Ambeed A529842 (S)-tert-Butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98+% 10mg $62 2021-12-16 Buy
Ambeed A529842 (S)-tert-Butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98+% 5mg $48 2021-12-16 Buy
ApexBio Technology A1910 BromodomainInhibitor,(+)-JQ1 50mg $500 2021-12-16 Buy
Arctom CFN60008 (+)-JQ1 20mg $70 2021-12-16 Buy
Biorbyt Ltd orb146221 (+)-JQ1 HPLC > 99%,ee > 99% 100mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb146221 (+)-JQ1 HPLC > 99%,ee > 99% 250mg $1060.8 2021-12-16 Buy
Biorbyt Ltd orb146221 (+)-JQ1 HPLC > 99%,ee > 99% 1g $2395.3 2021-12-16 Buy
Biosynth Carbosynth FC43273 (+)-JQ 1 10mg $125 2021-12-16 Buy
Biosynth Carbosynth FC43273 (+)-JQ 1 50mg $437.5 2021-12-16 Buy
Next Last

Properties

Melting point :>205°C (dec.)
Boiling point :610.4±65.0 °C(Predicted)
Density :1.33
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :2.05±0.60(Predicted)
color :white to beige
Stability :Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChIKey :DNVXATUJJDPFDM-KRWDZBQOSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. JQ1 displaces BET proteins from chromatin by competitively binding to the acetyl-lysine recognition pocket of BET bromodomains. Enantiomerically pure (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively, whereas the (?)-JQ1 stereoisomer has no appreciable affinity to BET bromodomains. JQ1 has been used as a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis. See the Structural Genomics Consortium (SGC) website for more information.

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Suppliers and manufacturers

career henan chemical co
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
$1.00 /1KG
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate CAS:1268524-70-4
Capot Chemical Co.,Ltd.
Nanjing ChemLin Chemical Industry Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
Zhejiang ZETian Fine Chemicals Co. LTD
Biochempartner
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd.
Hubei Jusheng Technology Co.,Ltd.
Accela ChemBio Inc.
Shandong chuangyingchemical Co., Ltd.