LY 2606368
- ₹0
- Product name: LY 2606368
- CAS: 1234015-52-1
- MF: C18H19N7O2
- MW: 365.39
- EINECS:
- MDL Number:MFCD25977016
- Synonyms:LY 2606368;5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile LY2606368;5-[[5-[2-(3-Aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-2-pyrazinecarbonitrile;5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile;Prexasertib;LY 2606368;LY-2606368;PREXASERTIB;Prexasertib (LY2606368);CS-1453
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Properties
Boiling point :608.5±55.0 °C(Predicted)
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in DMSO
form :A crystalline solid
pka :11.89±0.10(Predicted)
color :Light yellow to brown
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in DMSO
form :A crystalline solid
pka :11.89±0.10(Predicted)
color :Light yellow to brown
Safety Information
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Description
LY2606368 is a checkpoint kinase 1 (Chk1) inhibitor with a Ki value of 0.9 nM against the purified target and IC50 values of <13 nM in a viability study of multiple colorectal cancer cell lines. Inhibition of Chk1 causes double-strand DNA breakage in cells leading to an excessive cell damage burden and subsequent cell death. In vitro, LY2606368 inhibits the doxorubicin-activated G2/M checkpoint in p53-deficient HeLa cells with an EC50 value of 9 nM. LY2606368, at 25 nM, also significantly induces apoptosis and inhibits colony formation in AGS and MKN1 gastric cancer cells.More related product prices
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